Immunological Profile of HIV-Infected Patients with Tuberculosis Associated-Immune Reconstitution Inflammatory Syndrome: A Systematic Review
|Luana Leandro Gois1,2, Yuri Reis Casal1,2, Igor Libório Augusto Pedreira2, Antonio Carlos Bandeira3,4, Roberto Badaró5, Maria Fernanda Rios Grassi1,2*|
|1Fundação Oswaldo Cruz – Fiocruz, Salvador, Bahia, Brazil|
|2Escola Bahiana de Medicina e Saúde Pública – EBMSP, Salvador, Bahia, Brazil|
|3Hospital Couto Maia|
|4Faculdade de Tecnologiae Ciências, Salvador, Brazil|
|5Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Unidade docente de Infectologia, Salvador, BA, Brazil|
|Corresponding Author :||Maria Fernanda Rios Grassi
Rua Waldemar Falcão
121, Candeal - Salvador/BA- Brazil
Tel: +55 (71) 3176-2213
E-mail: [email protected]
|Received May 27, 2015; Accepted June 28, 2015; Published June 30, 2015|
|Citation: Gois L L, Casal Y R, Pedreira ILA, Bandeira AC, Badaro R (2015) Immunological Profile of HIV-Infected Patients with Tuberculosis Associated-Immune Reconstitution Inflammatory Syndrome: A Systematic Review. J Clin Cell Immunol 6:337. doi: 10.4172/2155-9899.1000337|
|Copyright: © 2015 Gois LL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: This study systematically reviews the literature that describes the immunological profile associated with the development of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIVinfected individuals.
Methods: Between the primary and secondary searches, a total of 20 articles were selected for the final analysis.
Results: The results obtained herein indicated that TB-IRIS was associated with the recovery of Mtb-specific immune response, demonstrated by an increased frequency of specific IFN-g-producing cells and specific multifunctional T-lymphocytes (TNF and IFN-γ-producing). In addition, an increased production of inflammatory cytokines and chemokines was found in TB-IRIS patients compared to non-IRIS individuals.
Conclusion: These data suggest that expansion of Mtb-specific cells may not be the main factor for the occurrence of IRIS. Further studies are needed to better evaluate the dynamic of restoration of Mtb-specific memory cells and to clarify the role of innate immune responses in immunopathogenesis of TB-IRIS patients