alexa Immunomodulatory Studies on Triterpenoids from Scoparia dulcis Linn
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Research Article

Immunomodulatory Studies on Triterpenoids from Scoparia dulcis Linn

Khaga Raj Sharma1,2, Achyut Adhikari1, Almas Jabeen3, Nida Dastagir3, Surya Kant Kalauni2, M Iqbal Choudhary1,3,4 and Yuba Raj Pokharel5*
1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
2Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal
3Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi-75270, Pakistan
4Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah-21412, Saudi Arabia
5Faculty of life science and Biotechnology, South Asian University, Chankyapuri, New Delhi, India
Corresponding Author : Yuba Raj Pokharel
Faculty of Life Science and Biotechnology
South Asian University, Chankyapuri
New Delhi, India 110021
Tel: +91-11-24122512-14
E-mail: [email protected]
Received: July 22, 2015 Accepted: August 13, 2015 Published: August 17, 2015
Citation: Sharma KR, Adhikari A, Jabeen A, Dastagir N, Kalauni SK, et al. (2015) Immunomodulatory Studies on Triterpenoids from Scoparia dulcis Linn Biochem Pharmacol (Los Angel) 4:182. doi:10.4172/2167-0501.1000182
Copyright: © 2015 Sharma KR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Glutinone (1), coixol (2), friedelin (3), glutinol (4), and betulinic acid (5) were isolated from the plant Scoparia dulcis. Their structures were identified using mass and 1D- and 2D- NMR techniques. All the compounds were tested for their immunomodulatory potential in oxidative burst assay. Compound 1 showed a significant inhibitory effect on the release of reactive oxygen species (ROS) from zymosan activated cells from whole blood (IC50 = 4.3 ± 0.6 μg/mL) as well as from isolated PMNs (IC50 = 5.0 ± 0.3 μg/mL) as compared to standard drug ibuprofen in whole blood (IC50 = 11.2± 1.9 μg/ mL) and in isolated PMNs (IC50 = 2.5± 0.6 μg/mL) shows that it is more active in whole blood as compared with isolated PMNs. Compound 1 when further tested for its effect on pro-inflammatory cytokines TNF-α, IL-1β and on nitric oxide (NO), was found to moderately inhibiting the production of TNF-α (19%) at a concentration 25 μg/mL. On the other hand a weak inhibitory effect of this compound was also observed on the production of IL-1β and NO production, whereas, compounds 2-5 showed no effect (IC50 = >100) on the release of ROS from zymosan activated cells.

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