alexa Immunopathology during African Trypanosomosis
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Review Article

Immunopathology during African Trypanosomosis

Jennifer Cnops1,2, Magdalena Radwanska3 and Stefan Magez1,2*

1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium

2Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium

3Ghent University Global Campus, Incheon, South Korea

*Corresponding Author:
Stefan Magez
Laboratory of Cellular and Molecular Immunology
Vrije Universiteit Brussel, Brussels, Belgium
Tel: 32-(0)2-629 19
E-mail: [email protected]

Received Date: December 11, 2015 Accepted Date: December 30, 2015 Published Date: January 06, 2016

Citation: Cnops J, Radwanska M, Magez S (2016) Immunopathology during African Trypanosomosis. J Trop Dis 4:197. doi:10.4172/2329-891X.1000197

Copyright: © 2016 Cnops J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

African trypanosomes are the causative agents of Human African Trypanosomosis (HAT), otherwise termed ‘Sleeping Sickness’, and Animal African Trypanosomosis (AAT) or ‘Nagana’. These parasites infect humans and animals throughout the African continent, where they cause death and impair economic development. In this review we describe the events leading to the onset of inflammation in the mouse model for trypanosomosis, and we describe two important pathological features associated to the acute pro-inflammatory reaction: anemia and B cell destruction.

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