Immunopathology of Central Nervous System TumorsChristopher R Showers*, Adam M Sonabend and Richard CE Anderson
The Gabriele Bartoli Brain Tumor Research Laboratory, Department of Neurological Surgery, The Neurological Institute, Columbia University College of Physicians and Surgeons, New York City, NY 10032, USA
- *Corresponding Author:
- Christopher R Showers
The Gabriele Bartoli Brain Tumor Research Laboratory
Department of Neurological Surgery, The Neurological Institute
Columbia University College of Physicians and Surgeons New York City, NY 10032, USA
E-mail: [email protected]
Received date: March 12, 2014; Accepted date: April 26, 2014; Published date: May 05, 2014
Citation: Christopher R Showers Adam M Sonabend, Richard CE Anderson (2014) Immunopathology of Central Nervous System Tumors. Immunome Res 10:077. doi: 10.4172/1745-7580.1000077
Copyright: © 2014 Showers CR et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The central nervous system (CNS) is characterized by unique immune biology. Distinct mechanisms of CNS immune surveillance and activation have important implications in tumor development as CNS tumors are known to evade anti-tumoral immunity, and may also contribute to immunosuppression. Multiple cell-surface and secreted mediators, expressed in both CNS tumor cells and responding immune cells, have been shown to influence the immune response to CNS tumors. In this review we provide an overview of CNS tumor immune escape and immunosuppression, highlighting the cellular and molecular features associated with both CNS tumors cells and responding immune cells. In this context, we discuss of the role of the M1 and M2 tumor associated macrophage phenotypes, myeloid derived suppressor cells, regulatory T-cells, as well as many immunomodulatory cytokines. Additionally, recent insights into the STAT-3 intracellular signaling pathway and the presence of active human CMV infection in the context of CNS tumor development are discussed.