alexa Immunopharmacological Activity of Saponin from Terminalia arjuna and Prosopis spicigera

Journal of Pharmacological Reports
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Research Article

Immunopharmacological Activity of Saponin from Terminalia arjuna and Prosopis spicigera

Amit Gupta* and Sushama R Chaphalkar
Department of Immunology and Virology, Vidya Pratishthan’s School of Biotechnology, Maharashtra, India
Corresponding Author : Amit Gupta
Assistant Professor (Immunology)
Department of Immunology and Virology
Vidya Pratishthan’s School of Biotechnology
(VSBT Research Centre affiliated to Savitribai
Phule Pune University) Baramati, Maharashtra, India
Tel: +918308881506
E-mail: [email protected]; [email protected]; [email protected]
Received December 07, 2015; Accepted December 29, 2015; Published December 31, 2015
Citation: Gupta A, Chaphalkar SR (2015) Immunopharmacological Activity of Saponin from Terminalia arjuna and Prosopis spicigera. J Pharma Reports 1:102. doi:10.4172/jpr.1000102
Copyright: © 2015 Gupta A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The aim of the present work was to examine the immunopharmacological (anti-microbial and anti-inflammatory) effect of saponin on human peripheral blood mononuclear cells (PBMC) that are isolated as well as purified from infected (virally) and non-infected (normal) human whole blood samples. However, there is little information available concerning the effect of crude saponin on human PBMC in case of infected and non-infected human PBMCs. Saponin, one of the members of secondary metabolites that are isolated from aqueous leaves extract of Terminalia arjuna and Prosopis spicigera. Our group evaluated the immunopharmacological activity of saponin (0.5–30 mg/ml, 100 μl) in human PBMC were determined and measured cell proliferation using Concanvalin (Con A, 2.5 μg/ml, 50 μl) and estimate Th1 (IFN-gamma and TNF alpha) type of cytokines from cell culture supernatant including nitric oxide production. The results showed that crude saponin from Terminalia arjuna and Prosopis spicigera showed its inhibitory activity at higher doses (30 mg/ml, 100 μl) in Con A induced PBMC (infected and non-infected) proliferation. In addition, these saponin also inhibits its Th1 (IFN-gamma and TNF alpha) type of cytokines from Con A stimulated cell culture supernatant of PBMC and also inhibits nitric oxide production in a dose dependent manner. In conclusion, saponin appears to have potential as an anti-microbial and anti-inflammatory agent.

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