alexa Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Research Article

Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis

Walaa Fikry Mohammed Elbossaty*

Department of Chemistry, Biochemistry Division, Faculty of Science, Damietta University, Damietta, Egypt

*Corresponding Author:
Walaa Fikry Mohammed Elbossaty
Department of Chemistry, Biochemistry Division
Faculty of Science, Damietta University
Damietta, Box 34517, Egypt
Tel: 020573761683
E-mail: [email protected]

Received Date: December 23, 2016 Accepted Date: January 30, 2017 Published Date: February 02, 2017

Citation: Elbossaty WFM (2017) Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis. J Mol Biomark Diagn 8: 328. doi: 10.4172/2155- 9929.1000328

Copyright: ©2017 Elbossaty WFM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antigen surface markers represent as the new prognostic tool for detection of acute leukemia. To investigate the prevalence expression of lymphoid and myeloid antigen lineage in acute leukemias. This study included 100 acute leukemias patients. Specimens were selected from consecutive patients who had sufficient material available. Among the 100 patients in which a detailed history, hematological, clinical and immunophenotyping analysis were performed. This study was showed distribution of immunophenotyping characters between studied AML and ALL cases. The most abundant immunophenotyping features in acute myeloid leukemia were cMPO, CD33, CD117, CD13, CD14 and CD64, while the most abundant immunophenotyping features in acute lymphoblastic leukemia were CD19, CD79a, TdT, CD20, CD10 and CD34. cMPO which act as independent prognostic factor for AML, CD10 and TdT can used as independent prognostic factor for differentiate between ALL and AML.

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