Immunosuppression Induced by HIV InfectionMohamed G Elfaki*
Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre and Alfaisal University College of Medicine, Riyadh, Saudi Arabia
- *Corresponding Author:
- Mohamed G Elfaki
Department of Infection and Immunity
King Faisal Specialist Hospital & Research Centre
P.O. Box 3354, MBC 03, Riyadh 11211, Kingdom of Saudi Arabia
E-mail: [email protected]
Received date: July 17, 2014; Accepted date: August 20, 2014; Published date: August 27, 2014
Citation: Mohamed G. Elfaki (2014) Immunosuppression Induced by HIV Infection. Biol Med 6:e111 doi:10.4172/0974-8369.1000e111
Copyright: © 2014 M.G. Elfaki, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Immunosuppression due to HIV infection is a resultant of several factors including defective innate signaling pathways, increased viral replication and virus load, gradual loss of peripheral CD4+T cells and depletion of T lymphocytes at mucosal sites that collectively lead to progressive immune deficiency and AIDS development. T cells derived from HIV patients were anergic and failed to mount a robust adaptive immune response. The host, on the other hand, becomes vulnerable to opportunistic infections such as tuberculosis and AIDS-related cancer such as Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer with remarkable level of immunosuppression. Elucidation of the various mechanisms involved in these immunologic perturbations is necessary to understand HIV pathogenesis for an effective immunotherapy.