Immunotherapy of 436 Morphine Addicts by Therapeutic Morphine Vaccine in Kerman Province (I.R. Iran)
Ali Farhangi, Azim Akbarzadeh*, Mohammd Reza Mehrabi, Mohsen Chiani, Zahra Saffari, Mehri Mortazavi and Soheil Ghassemi
Pilot Biotechnology Department, Pasteur Institute of Iran, No. 358, 12 Farvardin Street, Jomhoori Avenue, Tehran, Iran
- *Corresponding Author:
- Dr. Azim Akbarzadeh
Head & Full Professor of Pilot Biotechnology Department
Pasteur Institute of Iran, No. 358
12 Farvardin Street, Jomhoori Avenue
Tehran, Iran, 13169- 43551
Tel: + 98- 21- 6646 5406
Fax: + 98- 21- 6646 5132
E-mail: [email protected]
Received date: October 09, 2012; Accepted date: October 15, 2012; Published date: October 18, 2012
Citation: Farhangi A, Akbarzadeh A, Mehrabi MR, Chiani M, Saffari Z, et al. (2012) Immunotherapy of 436 Morphine Addicts by Therapeutic Morphine Vaccine in Kerman Province (I.R. Iran). J Vaccines Vaccin 3:154.doi:10.4172/2157-7560.1000154
Copyright: © 2012 Farhangi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Morphine vaccine is synthesized by conjugation of morphine- 6- hemisuccinate with BSA. In This Study, 436 addicted volunteers were immunized by morphine vaccine. They were first bled and then received three doses of morphine vaccine on 0, 30 and 60 days. Each dose of injected morphine vaccine contained 50 μg Morphine- 6-succinat –BSA, 0.5 mg Aluminum hydroxide (Al3+), 8 mg Sodium chloride, 1.12 mg Dibasic sodium phosphate anhydrous, 1.1 mg Monobasic sodium phosphate monohydrate and 1 ml Water for injection. After 90 days, all subjects were bled and after 1 year of immunization, 10% of them were bled randomly and total protein, gamma globulin and anti-morphine antibody levels were determined. The amounts of total protein, gamma globulin and antimorphine antibody decreased but did not reach the base line even one year after the last dose of injection. Morphine vaccine has been well tolerated systematically and prevents the vaccinated morphine addicts to restart morphine consumption because the antibody destroys the in taken (consumed) morphine.