alexa Impact of Art Mother and Child on The HIV Status of the
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Research Article

Impact of Art Mother and Child on The HIV Status of the Child Born to HIVPositive Mothers in Burkina Faso: Towards the Adoption of an Effective Pmtct Policy

Sourabie Y1,2, Ouedraogo SM1,2*, Bazie WW1, Sanodji N1,3, Barro M1, Ouattara ABI1, Traoré Y4 and Nacro B1,2
1Sourô Sanou university hospital, Mail box 676 Bobo-Dioulasso 01, Burkina Faso
2Higher institute of Health sciences, Polytechnic University of Bobo Dioulasso, Burkina Faso
3Department of Health sciences, University of Ouagadougou, Burkina Faso, Burkina Faso
4Department of the Sciences and Technologies, University of Ouagadougou, Burkina Faso
Corresponding Author : Ouedraogo S Macaire
Doctor internist to the University hospital Souro Sanou
University hospital professor
Department of internal medicine
immunology and hematology Mail box 676
Burkino Faso
Tel: 00226 70207076
E-mail: [email protected]
Received February 19, 2015; Accepted March 16, 2015,; Published March 23, 2015
Citation: Sourabie Y, Ouedraogo SM, Bazie WW, Sanodji N, Barro M, et al. (2015) Impact of Art Mother and Child on The HIV Status of the Child Born to HIV-Positive Mothers in Burkina Faso: Towards the Adoption of an Effective Pmtct Policy. J Hematol Thrombo Dis 3:198. doi:10.4172/2329-8790.1000198
Copyright: © 2015 Sourabie Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: To evaluate the impact of ART of the mother and the child on the HIV status of children born to HIV positive mothers in compliance with the policy of mother-child transmission (PMTCT) adopted in Burkina Faso. Method: It is a prospective cohort study. 214 HIV-positive mother - infant pairs were involved over a period of 14 months (2011-2013). Early pediatric laboratory biologic diagnosis of HIV infection with children aged from 6 weeks to 18 months was carried out by RNA/PCR of HIV1 (Kit Biocentric®). Children with viral load lower than 300 copies/mL (>2.48 Log) were considered uncontaminated. All the children were clinically and biologically followed up to 18 months, the age at which an immunochromatographic test (Determine®) and an ELISA test (Immunocoomb II BiSpot HIV1 2®) were made to confirm their serological status. We determined the immunological status of positive mothers through a numeration of TCD4 + lymphocytes on a flow cytometer (FacscountV1.5). HIV positive Women were dispatched following treatment systems in accordance with options A and B + (mothers on nevirapine alone, mothers on highly active antiretroviral therapy (HAART)/mothers without HAART). Results: The median age of the children was 6 months (1.5-18 months). The sex ratio was 0.79. The infection rate was 11.2% (24/214). The MTCT was significantly higher among mothers without HAART on Nevirapine only (22/41) than among those on HAART (2/172) p=0.0000 2. The proportion of children infected through breastfeeding whose mothers were not on HAART (23/23) was significantly higher than those whose mothers were on HAART (0/139) p=0.0000 12. Conclusion: According to the guidelines combined on the use of antiretroviral for the treatment and prevention of HIV infection (June 2013), we also recommend for Burkina Faso, the abandonment of Option A and the adoption of option B + with all pregnant women whatever their immune-clinical status.

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