alexa Impact of Cadmium on the Endocrine and Exocrine Sexual Activity in the Adult Male and Female Wistar Rats: Determination of an Apoptotic Process | OMICS International| Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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  • Research Article   
  • J Environ Anal Toxicol 2018, Vol 8(1): 552
  • DOI: 10.4172/2161-0525.1000552

Impact of Cadmium on the Endocrine and Exocrine Sexual Activity in the Adult Male and Female Wistar Rats: Determination of an Apoptotic Process

Manel Boujelben1, Raed Abdennabi2,3*, Fadhel Guermazi4 and Abdelfattah Elfeki1
1Laboratory of Animal Ecophysiology, Faculty of Sciences, , Sfax, Tunisia
2Laboratory of Plant Biotechnology, Faculty of Sciences, University of Sfax, BP 1171, 3000, Tunisia
3Laboratory of Pharmacognosy and Natural Products Chemistry, , Athens 15771, Greece
4Laboratory of Nuclear Medicine, CHU Habib-Bourguiba of Sfax, , Tunisia
*Corresponding Author : Raed Abdennabi, Laboratory of Pharmacognosy and Natural Products Chemistry, Athens 15771, Greece, Tel: +21698694398, Email: [email protected]

Received Date: Feb 16, 2018 / Accepted Date: Feb 25, 2018 / Published Date: Feb 28, 2018

Abstract

This study deals with the impact of chronic exposure to cadmium on male and female’s fertility in rats. In fact, some male and female rats are given distilled water for drinking (T: controls), whereas the other ones are given distilled water enriched with chloride cadmium, either 10 (C1 group) or 20 mg/l (C2 group) for 1, 5, 10, 15, 30, 45, 60 or 90 days. In male rats, Cadmium, which induced a pathological change in spermatogenesis, is observed by histological studies: arrest of cell germ maturation, Then, an alteration of the structure of the seminiferous tubes with blockage of spermatogenesis (presence of male gametes without flagella or total absence of spermatozoa and destruction of the sertoli cells, testified by the presence of spans). Then, a decrease of the motility and the number of spermatozoa at the end of the treatment indicates the local cytotoxic effect of cadmium (Cd) on spermatogenesis, inducing an apoptotic phenomenon revealed by borated toluidine blue in the testicular cells, which affects the different stages of spermatogenesis. Serum testosterone level is found to be low at the beginning of the treatment, reaches a peak, then returns to the control values and even exceeds them in spite of the continuation of the treatment. It is therefore a hormonal adaptation to this pollutant. In female rats, the practiced vaginal smears revealed the oestrus phase in all the groups. Exposed females are mated to control males, and fertility is assessed later by counting the number of pregnancies. Fertility is found to be reduced in females of C1 and C2 groups as compared to control females (T group).

Keywords: Cadmium; Rat; Fertility; Apoptosis

Citation: Boujelben M, Abdennabi R, Guermazi F, Elfeki A (2018) Impact of Cadmium on the Endocrine and Exocrine Sexual Activity in the Adult Male and Female Wistar Rats: Determination of an Apoptotic Process. J Environ Anal Toxicol 8:552. Doi: 10.4172/2161-0525.1000552

Copyright: © 2018 Boujelben M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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