alexa Impact of Chromosomal Heteromorphisms on Recurrent Miscarriages | OMICS International | Abstract
ISSN: 2161-0436

Human Genetics & Embryology
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Impact of Chromosomal Heteromorphisms on Recurrent Miscarriages

Sandesh Chopade1*, Chopade DK2 and Harish Harde2

1Department of Bioengineering, IIT, Kanpur, India

2Genetic Health & Research Center, 7, Mahatmanagar, Nashik, Maharashtra, India

*Corresponding Author:
Sandesh Chopade
Department of Bioengineering
IIT, Kanpur, India
E-mail: [email protected]

Received Date: April 15, 2012; Accepted Date: July 11, 2012; Published Date: July 11, 2012

Citation: Chopade S, Chopade DK, Harde H (2012) Impact of Chromosomal Heteromorphisms on Recurrent Miscarriages. Human Genet Embryol 2:101. doi: 10.4172/2161-0436.1000101

Copyright: © 2012 Chopade S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Chromosomal Heteromorphisms are the inherited variations at specific chromosomal regions without a proven impact on the phenotype of an individual. Material and Methods: We studied and compared the chromosome Heteromorphisms in the Karyotypes of two groups. The first group consisted of 320 individuals of 160 couples with more than two miscarriages and no live birth and the second group consisted of 412 individuals of 206 normal couples with more than 1 normal child birth. Results and discussion: Twenty Nine individuals (9.06%) with a history of recurrent pregnancy loss were found to have chromosomal heteromorphisms, whereas thirteen individuals (3.1%) from the normal group were having the chromosomal heteromorphism. The difference between the two groups was statistically significant (p<0.0001) Conclusion: These results are consistent with other similar studies that suggest the yet undefined relationship between chromosome heteromorphism and recurrent pregnancy loss.

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