alexa Impact of Combination Interferon Therapy on the Body We
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Impact of Combination Interferon Therapy on the Body Weight, Body Fat and Lean Body Mass of Chronic HCV Infected Patients

Ibrar Alam1,2, Ijaz Ali1 , Sajid Ali3 *, Iftikhar Alam4,5, Farzana1 and Zeeshan Naseem1

1 Institute of Biotechnology and Genetic Engineering (IBGE), KP, Agricultural University, Peshawar, Pakistan

2 Department of Biotechnology, Bacha Khan University, KPK, Pakistan

3 Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan

4 Department of Human Nutrition & Dietetics, Baha Khan University, KPK, Pakistan

5 Tübingen Ageing and Tumour Immunology Group, Zentrum für Medizinische Forschung, University of Tübingen, Germany

*Corresponding Author:
Sajid Ali
Assistant Professor
Centre of Biotechnology and Microbiology
University of Peshawar, Pakistan
Tel: 92-0346911693
E-mail: [email protected]

Received Date: November 26, 2013; Accepted Date: December 29, 2013; Published Date: December 31, 2013

Citation: Alam I, Ali I, Ali S, Alam I, Farzana, et al. (2013) Impact of Combination Interferon Therapy on the Body Weight, Body Fat and Lean Body Mass of Chronic HCV Infected Patients. J Antivir Antiretrovir 6:001-005. doi: 10.4172/jaa.1000087

Copyright: © 2013 Alam I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Changes in body weight in HCV patients on interferon therapy are well established. However, these are not reported extensively in patients from developing societies, where the infection may have different dimensions. Also, most of the previous studies reported changes in body weight only but not in other compartments of body composition, which have numerous clinical implications. We, therefore, prospectively investigated these changes in current study. The study comprised 30 HCV positive patients, recruited from Khyber Teaching Hospital (KTH) Peshawar, Pakistan. Patients were screened for antibodies against HCV. The positive samples were subjected to polymerase chain reaction (PCR) analysis for detection of HCV-RNA and were entered into two groups: one group (‘on therapy’ (n=20) received Interferon (IFN) therapy, while the other group (‘no therapy’ (n=10) did not. Data were collected for weight, height, nutrition and other socio-demographic parameters. Body composition was assessed using bio-electric impedance analysis (BIA) and monitored for the six months of treatment. The major findings of this research study are significant (p ≤ 0.05) reduction in body weight, body fat (BF) and lean body mass (LBM) in HCV patients on interferon-α (IFN-α) therapy. These parameters changed non-significantly (p, trends for all>0.05) in ‘no therapy’ group. The greatest effects of these changes were demonstrated in month 1-4 of treatment. In conclusion, interferon therapy causes significant reduction in compartments of body composition and that these changes may be considered to be used as surrogate indicators for monitoring the treatment efficacy.

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