Impact of Cytokine Gene Polymorphism on the HIV-1 Disease Progression and Response to Therapy
Sukhvinder Singh and Sunil K Arora*
Department of Immunopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- *Corresponding Author:
- Sunil K Arora
Department of Immunopathology
Postgraduate Institute of Medical Education and Research (PGIMER)
E-mail: [email protected]
Received date: August 11, 2015; Accepted date: October 09, 2015; Published date: October 15, 2015
Citation: Singh S, Arora SK (2015) Impact of Cytokine Gene Polymorphism on the HIV-1 Disease Progression and Response to Therapy. J AIDS Clin Res 6:506. doi:10.4172/2155-6113.1000506
Copyright: © 2015 Singh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Inter-individual variations in HIV infection outcome indicate a role of host genetic variations in the HIV disease progression and response to therapy. Cytokines are early key players in HIV infection, which influence the infection outcome by regulating viral replication, persistence and eradication of its reservoirs as well as host immune response. Genetic variations in cytokine genes can alter protein expression resulting in differential infection outcome. In this review we have summarized the available literature on cytokine and receptor variations in HIV infection outcome and response to therapy. A better understanding of cytokine genetic variation in HIV disease progression and response to therapy will help clinicians in better management of HIV infected individuals.