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ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Impact of Cytokines on Neural Stem/Progenitor Cell Fate

Jocelyn Breton1 and Yang Mao-Draayer2*

1Middlebury College, Middlebury, VT 05753

2Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405

*Corresponding Author:
Yang Mao-Draayer
Department of Neurology
University of Vermont College of Medicine
Burlington, VT 05405
Tel: 802-656-8984
Fax: 802-656-4674
E-mail: [email protected]

Received August 15, 2011; Accepted November 01, 2011; Published November 18, 2011

Citation: Breton J, Mao-Draayer Y (2011) Impact of Cytokines on Neural Stem/ Progenitor Cell Fate. J Neurol Neurophysiol S4. doi: 10.4172/2155-9562.S4-001

Copyright: © 2011 Breton J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Neural stem/progenitor cells (NSC/NPC) can be a powerful tool for the neural repair of the damaged brain. Many of the current challenges with stem cell therapies revolve around the problem that stem cells do not survive, migrate, proliferate and differentiate as much as hoped. Understanding the interaction between NPCs and the immune system is essential for the effective use of stem cell transplantation. Cytokines play an important role in determining the inflammatory microenvironment and have also been shown to have effects on the differentiation, proliferation, migration and survival of NPCs. The effects of cytokines on neural stem cell fate is more complex than once believed; the distinction between anti-inflammatory and pro- inflammatory cytokines is not straightforward and varies based on conditions such as cytokine concentration and area of transplantation. If their role is understood, cytokines could be used to improve the efficacy of stem cell treatments and enhance neural repair. In this review, we provide a comprehensive overview of the effects of various cytokines on NPC fate. The ultimate goal of this review is to demonstrate how manipulation of the CNS microenvironment through alteration of various cytokines can enhance the capacity of NPC differentiation, proliferation, and overall neural repair.

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