alexa Impact of Integrating Pet-Ct in Radiotherapy Planning of Non-small Cell Carcinoma Lung: Dosimetric and Radiobiological Comparison | OMICS International
ISSN: 2329-6771

Journal of Integrative Oncology
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Research Article

Impact of Integrating Pet-Ct in Radiotherapy Planning of Non-small Cell Carcinoma Lung: Dosimetric and Radiobiological Comparison

Deepak Koppaka1, Rakesh Kapoor1, Amit Bahl1, Anshuma Bansal1, BR Mittal2 and Navneet Singh3
1Department of Radiotherapy, PGIMER, Chandigarh, India
2Department of Nuclear Medicine, PGIMER, Chandigarh, India
3Department of Pulmonary Medicine, PGIMER, Chandigarh, India
Corresponding Author : Deepak Koppaka
Department of Radiotherapy, Nehru Hospital
PGIMER, Sector 12, Chandigarh
Tel: 09592096223
E-mail: [email protected] gmail.com
Received June 26, 2015; Accepted July 13, 2015; Published July 20, 2015
Citation: Koppaka D, Kapoor R, Bahl A, Bansal A, Mittal BR, et al. (2015) Impact of Integrating Pet-Ct in Radiotherapy Planning of Non-small Cell Carcinoma Lung: Dosimetric and Radiobiological Comparison. J Integr Oncol 4:139. doi:10.4172/2329-6771.1000139
Copyright: © 2015 Koppaka D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The integration of PET and CT scans allows the simultaneous use of biologic and anatomic imaging data for better delineating tumor and sparing normal critical structures. The aim of this study is to assess the impact on target volume delineation using CT vs. PETCT based plans, and to determine radiobiological effect on tumor and normal tissue by comparing Tumor control probability (TCP) & normal tissue complication probability (NTCP) of CT & PET-CT based plans. 15 patients of inoperable NSCLC planned for radical radiotherapy, underwent a planning CT scan of the thorax. Target volumes were contoured. Later PETCT images with the auto contoured MTV (Metabolic target volume) images, were fused with the planning CT images. Margins were similarly given to PETMTV for the generation of PET CTV and PET PTV. 3 Dimensional conformal radiotherapy (3DCRT) plans were made on the planning CT images and the planning PETCT images, and were compared dosimetrically and radio biologically. The study shows that the use of PETCT resulted in significant decrease in PETCT generated MTV versus GTV delineated on CT. Also, there was statistical significant decrease in the volume of the normal lung irradiated in terms of V40 and the MLD. TCP for PETCT based plans was significantly higher than that with CT based plans. Also, PETCT based planning resulted in a statistically significant decrease in the NTCP for lung and spinal cord. Therefore, the study concludes that incorporation of PETCT into radiotherapy planning of NSCLC is technically feasible and dosimetrically appealing strategy for patient treatment.

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