alexa Impact of Interleukin 16 (IL-16) Gene Polymorphism amon
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Impact of Interleukin 16 (IL-16) Gene Polymorphism among Seropositive Stages in HIV-1 Infected Patients in North India

Kavita Kakkar1,3, Swati Sharma1,3, Animesh Chatterjee1, Satyendra K Singh1, Sushma Singh2, Nikky Nyari1, Tapan N Dhole1*, Vikas Agarwal2 and Sayali Mukherjee3
1Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
2Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
3Amity Institute of Biotechnology, Amity University, Lucknow, India
Corresponding Author : Tapan N Dhole
MD, Department of Microbiology, Sanjay Gandhi
Postgraduate Institute of Medical Sciences, Lucknow-226014,India
Tel: +91-522-2494263
Fax: +91-522-2668100/+91-522-2668017
E-mail: [email protected]
Received: November 01, 2015; Accepted: January 04, 2016; Published: January 14, 2016
Citation: Kakkar K, Sharma S, Chatterjee A, Singh SK, Singh S, et al. (2016) Impact of Interleukin 16 (IL-16) Gene Polymorphism among Seropositive Stages in HIV-1 Infected Patients in North India. J Antivir Antiretrovir 8:006-010. doi:10.4172/ jaa.1000128
Copyright: © 2016 Kakkar K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: Cytokines have a major role in host immune defense system, and proinflammatory cytokines acts in both innate and immune systems. IL-16 is a pleiotropic cytokine, plays a role in inflammatory diseases and is involved in expression of several proinflammatory cytokines i.e., TNF-α and IL-1β. Previous studies reached inconclusive results regarding the role of IL-16 polymorphism on HIV-1 disease and progression. Hence, we studied its effects on HIV-1 infection and disease susceptibility.

Aim: This study aims to deduce the association of host genetic factors, IL-16 (rs 11556218, rs 4072111, rs 47778889) polymorphism on HIV-1 seropositive subjects in North Indian population.

Methods: 100 HIV-1 seropositive (HSP) subjects differentiated on the basis of disease severity (Stage I, II and III) and 150 HIV-1 seronegative (HSN) as control subjects were genotyped for IL 16 (rs 11556218 T/G, rs 4072111 C/T, rs 4778889 T/C using Polymerase chain reaction-reaction fragment length polymorphism (PCR-RFLP) methods. Statistical analysis was done using SPSS software.

Results: IL 16 rs 11556218 TG, GG genotypes (P=0.003 for both) and G allele was highly significantly associated (P<0.01) with risk estimated to 2.5, 4.4 and 2.59 folds. For IL 16 rs 407211 T allele was seen highly protective (P<0.01) for HIV-1.

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