Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) DietCrystal C Tyson1,2,3*, Maragatha Kuchibhatla4, Uptal D Patel1, Patrick H Pun1, Alex Chang5,6, Chinazo Nwankwo2,3, Michael A Joseph7 and Laura P Svetkey1,2,3
- *Corresponding Author:
- Crystal C Tyson, MD
Sarah W. Stedman Nutrition and Metabolism Center
3475, Erwin Road, Suite 100, Box 3487, Durham, NC 27705, USA
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Received Date: January 29, 2014; Accepted Date: August 01, 2014; Published Date: August 05, 2014
Citation: Tyson CC, Kuchibhatla M, Patel UD, Pun PH, Chang A, et al. (2014) Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet. J Hypertens 3:168. doi:10.4172/2167-1095.1000168
Copyright: © 2014 Tyson CC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies the effect of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function.
Methods: Secondary analysis of the DASH-Sodium trial, a multicenter, randomized, controlled human feeding study that evaluated the blood pressure lowering effect of the DASH diet at three levels of sodium intake. Data from 92 participants with pre-hypertension or stage 1 hypertension during the 3450 mg /day sodium diet assignment contributed to this analysis. Stored frozen plasma and urine specimens were used to measure kidney related laboratory outcomes.
Results: Effects of the DASH diet on blood pressure, phosphorus, intact parathyroid hormone, creatinine, and albuminuria were not modified by baseline eGFR (mean 84.5 ± 18.0 ml/min/1.73 m2, range 44.1 to 138.6 ml/min/1.73 m2) or the presence of chronic kidney disease (N=13%).
Conclusions: The impact of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function does not appear to be modified by eGFR in this small subset of DASH-Sodium trial participants with relatively preserved kidney function. Whether greater reduction in eGFR modifies the effects of DASH on kidney related measures is yet to be determined. A larger study in individuals with more advanced kidney disease is needed to establish the efficacy and safety of the DASH diet in this patient population.