Impact of Microarray Technology in Influenza Virus Research and Diagnostics
Sanjay Mukherjee and Alok K. Chakrabarti*
Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune -411021, India
- *Corresponding Author:
- Alok K. Chakrabarti
Microbial Containment Complex
National Institute of Virology
Sus Road, Pashan, Pune-411021, India
E-mail: [email protected]
Received Date: November 26, 2011; Accepted Date: January 18, 2012; Published Date: January 30, 2012
Citation: Mukherjee S, Chakrabarti AK (2012) Impact of Microarray Technology in Influenza Virus Research and Diagnostics. J Proteomics Bioinform S6:002. doi:10.4172/jpb.S6-002
Copyright: © 2012 Mukherjee S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Influenza A viruses cause 300,000-500,000 deaths every year across the globe and are continues threat to public health. There have been five influenza pandemics till date. In spite of the recent advances in the field of virus research there is no steady vaccine against influenza A viruses. Flu shots are given every year in many countries but remain effective only for one season. One of the main reasons of vaccine ineffectiveness is the high mutation rate in the influenza A genome caused by a poor error prone replication mechanism and virus recombination in the host cells resulting in variation in antigenic proteins. In order to overcome this problem scientists have enabled different strategies to control virus infectivity. Now in place of viruses, host responses are studied and modified in order to obtain an effective immune response against the viruses. Also, new strategies like rapid large scale virus diagnosis and development of effective vaccines using reverse genetics technique are being used for improvement of antiviral counter measures. Microarray technique, which is a high throughput method for diagnosis as well as assessment of large number of biomolecules in one attempt, has played an important role in understanding the etiology and pathogenesis of influenza A viruses. In this review we have discussed significance of microarray technology in influenza virus research during last one decade and highlighted its application in extensive diagnostics and genome wide transcriptional profiling of host responses to virus infection.