alexa Impact of Oxidative Stress and Lipid Peroxidation Induc
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Research Article

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Moustafa A Abbassy1, Mamdouh A Marzouk1, Sameeh A Mansour2, Hassan A Shaldam3 and Abdel-Tawab H Mossa2*
1 Department of Plant Protection, Faculty of Agriculture, Damanhour University, Egypt
2 Environmental Toxicology Research Unit (ETRU), Pesticide Chemistry Department, National Research Centre (NRC), Tahrir Str., Dokki, Cairo, Egypt
3 Center for Environmental Monitoring, Ministry of Health, Egypt
Corresponding Author : Abdel-Tawab H. Mossa
Environmental Toxicology Research Unit (ETRU)
Pesticide Chemistry Department
National Research Centre (NRC)
Tahrir Str., Dokki, Cairo, Egypt
Tel: 202-01005038504
Fax: 202-33370931
E-mail: [email protected]
Received February 20, 2014; Accepted April 16, 2014; Published April 18, 2014
Citation: Abbassy A, Marzouk MA, Mansour SA, Shaldam HA, Mossa ATH (2014) Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambda-cyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc. J Environ Anal Toxicol 4:218. doi: 10.4172/2161-0525.1000218
Copyright: © 2014 Abbassy A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The present study was designed to investigate the effect of lambda-cyhalothrin (LCH) on lipid peroxidation, oxidative stress biomarkers and the activity of Cytochrome P450 in male rats and the protective role of zinc. LCH was administrated orally to rats at dose 2.6 mg/kg b.wt. (Which represents 1/10 LD50) with 3 doses per week for 6 weeks (dose period). Rats were divided into four groups, eight rats for, each: (I) control group, (II) zinc group (Zn dose 227 mg/l in drinking water), (III) LCH-treated groups and LCH-Zn group (IV) as in group II and III. The present results demonstrated that LCH induced significant alteration in the activity of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione-s-transferase, GST; glutathione peroxidase, GPx), glutathione reduced (GSH) and lipid peroxidation (LPO) levels and decreased cytochrome P450 (P450) activity in plasma of male rats. In contrast, zinc-LCH treatment showed insignificant difference, compared to control results, regarding LPO, GST, CAT and P450. LCH induced oxidative stress, lipid peroxidation and reduced P450 activity in the plasma of male rats. The overall results reveal the pronounced ameliorating effect of zinc in LCH-intoxicated rats.

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