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ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Impact of Physical Inactivity on the Multifactorial Process of Developing Cancer-Related Cognitive Impairments

Pesendorfer LM1, Zimmer P1, Galvão DA2, Zopf EM3, Bloch W1 and Baumann FT1*

1Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Institute of Cardiovascular Research and Sport Medicine, Germany

2Exercise Medicine Research Institute, Edith Cowan University, Australia

3Institut for Health and Aging, Australien Catholic University, Melbourne Australia

*Corresponding Author:
Baumann FT
Department of Molecular and Cellular Sport Medicine, German Sport University Cologne
Institute of Cardiovascular Research and Sport Medicine, Am Sport park Müngersdorf 650933 Köln Germany
Tel: 02214982 4821
Fax: 02214982 8370
E-mail: [email protected]

Received date: July 04, 2016; Accepted date: August 29, 2016; Published date: August 31, 2016

Citation: Pesendorfer LM, Zimmer P, Galvão DA, Bloch W, Baumann FT (2016) Impact of Physical Inactivity on the Multifactorial Process of Developing Cancer- Related Cognitive Impairments. J Cancer Sci Ther 8:222-227. doi: 10.4172/1948- 5956.1000417

Copyright: © 2016 Pesendorfer LM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Many cancer survivors report cognitive impairment before, during and after medical treatment. It is well known that many factors other than chemotherapy take part in the development of these cancer- related cognitive impairments (CRCI), such as cancer-related fatigue, psychological as well as molecular factors. The purpose of this review is to describe the impact of physical inactivity in the genesis of these cognitive changes in cancer patients. References for this narrative review comes primarily from PubMed, Cochrane Library and Livivo databases. It contains literature search from October 2003 to April 2016. Our search was focused on available data for the influence of physical inactivity on cognitive performance of cancer patients. Cancer patients have decreased levels of physical activity during treatment. It is suggested that lack of physical activity in general is associated with cognitive decline. At present, most available data comes from trials with heart failure patients as well as results from bed rest studies in space medicine. The development of CRCI is a multifactorial process with physical inactivity appearing to play an important role. However, the available data remains limited and future trials are needed to examine the specific role of physical inactivity on CRCI.

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