alexa Impact of Simultaneous Exposure to Lead and Efavirenz on Some Biochemical Markers in Wistar Rats | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Impact of Simultaneous Exposure to Lead and Efavirenz on Some Biochemical Markers in Wistar Rats

Alain K. Aïssi1*, Lauris Fah1, Casimir D. Akpovi1, Jean Robert Klotoé1, Victorien T. Dougnon1,
Patient Guédénon2,Patrick A. Edorh2,3 and Frédéric Loko1
1 Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Benin
2 Interfaculty Center of Formation and Research in Environment for the Sustainable Development, Laboratory of Toxicology and Environmental Health, University of Abomey-Calavi (UAC), 01 BP 1463 Cotonou, Benin
3 Department of Biochemistry and Cellular Biology, Faculty of Science and Technology, University of Abomey-Calavi, Benin
Corresponding Author : Alain K. Aïssi
Research Laboratory in Applied Biology
Polytechnic School of Abomey-Calavi
University of Abomey-Calavi, Benin
Tél: +22995784471
E-mail: [email protected]
Received April 04, 2014; Accepted May 06, 2014; Published May 08, 2014
Citation: Aïssi AK, Fah L, Akpovi CD, Klotoé JR, Dougnon VT, et al. (2014) Impact of Simultaneous Exposure to Lead and Efavirenz on Some Biochemical Markers in Wistar Rats. J Environ Anal Toxicol 4:220. doi: 10.4172/2161-0525.1000220
Copyright: © 2014 Aïssi AK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Chronic exposure to heavy metals including lead remains a serious problem for humanity. The current study aims to evaluate the impact of co-exposure to lead (Pb) and Efavirenz (EFV) on some biochemical parameters in blood. Twenty eight Wistar rats were divided equally into four groups respectively orally fed with lead acetate at 10 mg/kg (GPb), EFV at 20 mg/kg (GEfv), both xenobiotics (GPb+Efv), and distilled water (GCtrl). On Day 0 and Day 28, the blood of each animal was collected and biochemical assays were conducted. Data were processed with SPSS 16.0. The results showed a significant decrease in total proteinemia, albuminemia, serum calcium and iron as well as a significant increase in blood urea and uric acid in group exposed to lead. The aforementioned changes were more pronounced in group GPb+Efv. Besides, significant increases in total cholesterolemia were observed in GEfv and GPb+Efv. In contrast, changes in blood glucose and triglycerides were not significant. In conclusion, this study highlights a real problem of public health, in the light of thousands of patients receiving antiretroviral therapy and who are unintentionally exposed to heavy metals.

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