alexa Impaired Executive Function by Interictal Epileptiform Discharges in Patients with Idiopathic Generalized Epilepsy
ISSN: 2472-0895

Epilepsy Journal
Open Access

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Research Article

Impaired Executive Function by Interictal Epileptiform Discharges in Patients with Idiopathic Generalized Epilepsy

Jiang Yubao*, Wu Jiaonan, Wang Yu, Zhou Nong and Wang Kai

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Sheng, China

*Corresponding Author:
Jiang Yubao
Department of Neurology
The First Affiliated Hospital of Anhui Medical University
Anhui Sheng, China
Tel: +86-551-62923704
E-mail: [email protected], [email protected]

Received Date: April 07, 2017; Accepted Date: April 21, 2017; Published Date: April 27, 2017

Citation: Yubao J, Jiaonan W, Yu W, Nong Z, Kai W (2017) Impaired Executive Function by Interictal Epileptiform Discharges in Patients with Idiopathic Generalized Epilepsy. J Epilepsy 3:118. doi: 10.4172/2472-0895.1000118

Copyright: © 2017 Yubao J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Many patients with Idiopathic Generalized Epilepsy (IGE) exhibit cognitive deficits. Interictal Epileptiform Discharges (IEDs) may contribute to cognitive impairment in epilepsy; however, the relationship between IEDs and cognitive impairment is unclear. Methods: In this study, we analysed executive function in three groups: IGE patients with IEDs, IGE patients without IEDs and healthy controls. Executive function was assessed using the Stroop Test, the Verbal Fluency Test, the Digit Span Test and Wisconsin Card-Sorting Test. Results: The IGE patients with IEDs performed worse on executive function tests compared with patients without IEDs. Furthermore, the IGE patients without IEDs performed worse compared with healthy controls. There were significant differences between the three groups in performance on the Stroop Test, the Digit Span Test (forward and backward), Verbal Fluency Test (animals, fruits) and the subscales of WCST (Categories Completed, Correct Response, Total Errors and Preservative Errors). Conclusion: These results suggest that executive function in patients with IGE is impaired and is further impaired by IEDs. Future studies should determine whether well-controlled patients with IGE could benefit from antiepileptic treatment.


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