Impaired Peripheral Circulation in Veterans with Claudication is Associated with SmokingAndrew W Gardner1,2,3*
- *Corresponding Author:
- Andrew W Gardner
University of Oklahoma Health Sciences Center (OUHSC)
Oklahoma City, USA
E-mail: [email protected]
Received Date: April 15, 2014; Accepted Date: August 20, 2014; Published Date: September 05, 2014
Citation: Gardner AW (2014) Impaired Peripheral Circulation in Veterans with Claudication is Associated with Smoking. Angiol 3:133. doi:10.4172/2329-9495.1000133
Copyright: © 2014 Gardner AW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We compared the peripheral vascular function of veterans and non-veterans with peripheral artery disease (PAD) and claudication. The circulation of the lower extremities was assessed under rest and reactive hyperemia conditions in 413 veterans and in 83 non-veterans. Veterans had more severe PAD as measured by a lower ankle/brachial index (p<0.001). Following the occlusive test, veterans had a greater relative percentage decrease in ankle systolic blood pressure (p=0.015), a greater percentage decrease in calf transcutaneous oxygen tension (p=0.035), and a blunted percentage increase in calf blood flow (p=0.031). After adjustment for current smoking status, these measures were no longer statistically different between the veterans and non-veterans. We conclude that veterans with PAD and claudication have greater impairments in macrovascular and microvascular function of the lower extremities, and greater severity of PAD than compared to non-veterans, and that these factors were primarily associated with their higher prevalence of smoking. The greater compromise in peripheral vascular measures in veterans is particularly noteworthy given that the prevalence of diabetes, hypertension, and dyslipidemia were not higher.