alexa Impaired Peripheral Circulation in Veterans with Claudication is Associated with Smoking | OMICS International
ISSN: 2329-9495

Angiology: Open Access
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Research Article

Impaired Peripheral Circulation in Veterans with Claudication is Associated with Smoking

Andrew W Gardner1,2,3*

1Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, USA

2Department of Medicine, Division of Gerontology, University of Maryland, Baltimore, USA

3Maryland Veterans Affairs Health Care System at Baltimore, USA

*Corresponding Author:
Andrew W Gardner
University of Oklahoma Health Sciences Center (OUHSC)
Oklahoma City, USA
Tel: 405-271-4272
Fax: 405-271-3887
E-mail: [email protected]

Received Date: April 15, 2014; Accepted Date: August 20, 2014; Published Date: September 05, 2014

Citation: Gardner AW (2014) Impaired Peripheral Circulation in Veterans with Claudication is Associated with Smoking. Angiol 3:133. doi:10.4172/2329-9495.1000133

Copyright: © 2014 Gardner AW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We compared the peripheral vascular function of veterans and non-veterans with peripheral artery disease (PAD) and claudication. The circulation of the lower extremities was assessed under rest and reactive hyperemia conditions in 413 veterans and in 83 non-veterans. Veterans had more severe PAD as measured by a lower ankle/brachial index (p<0.001). Following the occlusive test, veterans had a greater relative percentage decrease in ankle systolic blood pressure (p=0.015), a greater percentage decrease in calf transcutaneous oxygen tension (p=0.035), and a blunted percentage increase in calf blood flow (p=0.031). After adjustment for current smoking status, these measures were no longer statistically different between the veterans and non-veterans. We conclude that veterans with PAD and claudication have greater impairments in macrovascular and microvascular function of the lower extremities, and greater severity of PAD than compared to non-veterans, and that these factors were primarily associated with their higher prevalence of smoking. The greater compromise in peripheral vascular measures in veterans is particularly noteworthy given that the prevalence of diabetes, hypertension, and dyslipidemia were not higher.

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