alexa Impairment of Angiogenesis in Patients with Granuloma Annulare and Necrobiosis Lipoidica
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Impairment of Angiogenesis in Patients with Granuloma Annulare and Necrobiosis Lipoidica

Aleksandra Lesiak1*, Joanna Narbutt1, Iwona Słowik- Kwiatkowska2, Marian Danilewicz3 and Anna Wozniacka1

1 Department of Dermatology, Medical University of Lodz, Lodz, Poland

2 Internal Medicine Ward, General Hospital, Lublin, Poland

3 Department of Pathomorphology, Medical University Lodz, Lodz, Poland

*Corresponding Author:
Aleksandra Lesiak
Associate Professor
Department of Dermatology
Medical University of Łódź, Plac Hallera 1
90-647 Łódź, Poland
Tel: +48 426 867 981
Fax: +48 426 884 565
E-mail: [email protected]

Received date: May 15, 2014; Accepted date: July 7, 2014; Published date: July 14, 2014

Citation: Narbutt J, Kwiatkowska IS, Danilewicz M, Wozniacka A, Lesiak A (2014) Impairment of Angiogenesis in Patients with Granuloma Annulare and Necrobiosis Lipoidica . J Clin Exp Dermatol Res 5:226 doi: 10.4172/2155-9554.1000226

Copyright: © 2014 Aleksandra Lesiak. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Necrobiosis lipoidica (NL) and granuloma annulare (GA) belong to the granulomatous skin diseases with unclear pathogenesis. Despite the quite common occurrence of these entities in dermatological practice, research into the subject is limited. Thus, we decided to perform an immunohistochemical analysis of skin biopsies in order to assess the expression of selected proteins involved in angiogenesis. The study group consisted of 21 patients with NL and 23 with GA, selected from the database at the Department of Dermatology, Medical University of Łódź. Six healthy subjects served as the controls. Skin sections were stained with monoclonal antibodies directed against VEGF and CD34. The intensity of expression of epidermal VEGF, and the number of CD34+ dermal blood vessels were assessed. The mean intensity of VEGF immunoexpression in GA patients was 0.91, and was significantly higher than in either the NL patients (0.45; p<0.01) or the control group (0.14; p<0.009). The mean CD34+ microvessel density per mm2 in the GA group was 79.04, which was significantly higher than in the NL group (64.84; p<0.009) and in the controls (52.03; p<0.001). The obtained results confirm the similarity of the histological features of NL and GA. However, in GA, the biopsy changes in angiogenesis were more marked in the GL than in the NL group. In conclusion, based on our results we can assume that imbalance in the process of angiogenesis is one the factors involved in development of both NL and GA.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords