Implication of Endothelin-2 and Oxidative Stress Biomarkers in Essential HypertensionVeena Dhawan1*, Indu Sharma1, Nitin Mahajan1,3, Sonal Malik Sangwan1, and Sanjay Jain2
- *Corresponding Author:
- Veena Dhawan
Department of Experimental Medicine & Biotechnology, Research Block ‘B’
Postgraduate Institute of Medical Education & Research (PGIMER),Chandigarh-160012, India
E-mail: [email protected]
Received Date: May 20, 2014; Accepted Date: Aug 28, 2014; Published Date: September 02, 2014
Citation: Dhawan V, Sharma I, Mahajan N, Sangwan SM, Jain S (2014) Implication of Endothelin-2 and Oxidative Stress Biomarkers in Essential Hypertension. J Hypertens 3:170. doi:10.4172/2167-1095.1000170
Copyright: © 2014 Tyson CC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Essential hypertension (EH) is a multifactorial disease and oxidative stress has been demonstrated to play an important role in its pathophysiology. Among several genes implicated in the pathophysiology of hypertension, endothelin-2 (ET-2), a potent vasoconstrictor, has been incriminated as a candidate gene for essential hypertension. To find out correlation of in vivo biomarkers of oxidative stress [oxidized low density lipoprotein (Ox-LDL), 8-iso- Prostaglandin F2α (8-iso-PGF2α)] and Nitrite (NO2-) are related to endothelin-2 levels and to determine their value as diagnostic markers in essential hypertension.
Methods: 100 subjects with essential hypertension and 150 age and sex-matched normotensive controls were enrolled to determine levels of ET-2, Ox-LDL, 8-iso-PGF2α and NO2-.
Results: We observed significantly augmented levels of ET-2 (P<0.001), Ox-LDL (P<0.001), 8-iso-PGF2α (P<0.001) and nitrite (P<0.001) in EH subjects as compared to the normal healthy controls. ET-2 demonstrated a positive and significant correlation with Ox-LDL, 8-iso-PGF2α, and nitrite levels in subjects with EH. ROC curve analysis revealed that all these variables were significantly able to distinguish EH subjects and controls with high sensitivity and specificity.
Conclusions: TOur findings highlight implication of these variables as potential markers for the disease and as possible targets for therapeutic management of the essential hypertension.