Implication of Neuromodulation Therapy by Electroacupuncture in Treatment of DiabetesWei Zhou1*, Eileen L So2, Kentaro Yamakawa1 and Aman Mahajan1
- *Corresponding Author:
- Wei Zhou
David Geffen School of Medicine
University of California, 650 Charles E Young Dr S
CHS 56-131, Los Angeles, CA 90095, USA
E-mail: [email protected], [email protected]
Received date: May 24, 2013; Accepted date: June 24, 2013; Published date: June 30, 2013
Citation: Zhou W, So EL, Yamakawa K, Mahajan A (2013) Implication of Neuromodulation Therapy by Electroacupuncture in Treatment of Diabetes. J Diabetes Metab 4:270. doi: 10.4172/2155-6156.1000270
Copyright: © 2013 Zhou W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetes affects approximately 366 million individuals worldwide. Current pharmacological therapy is not perfect, and often is associated with adverse side effects. Acupuncture is used as an adjunctive treatment for a number of cardiovascular diseases. Chronic activation of the sympathetic nervous system has emerged as a key player in both the pathogenesis and progression of diabetes and metabolic syndrome. Recent evidence indicates that the down regulation of central nitric oxide system leads to an increased renal sympathetic neural activity in diabetic rats. Our experimental studies have shown that electroacupuncture stimulation exerts sympathoinhibitory effects through activation of neurons in the arcuate nucleus, ventrolateral gray, and nucleus raphe to inhibit the neural activity in the rostral ventrolateral medulla. This brief review will discuss current knowledge of the effects of acupuncture on central nervous system and provide a perspective on the future of treatment of diabetes with this alternative medicine technique.