alexa Improvement in Sperm DNA Quality Following Simple Life
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Improvement in Sperm DNA Quality Following Simple Life Style Intervention: A Study in Fathers of Children with Non-Familial Sporadic Heritable Retinoblastoma

www.omicsonline.org/searchresult.phpShiv Basant Kumar1, Surabhi Gautam1, Madhuri Tolahunase1, Bhavna Chawla2, Raj Kumar Yadav3,
Prabin Kumar4, D K Mitra4 and Rima Dada1*
1Department of Anatomy, Laboratory for molecular reproduction and genetics, All India Institute of Medical Sciences, New Delhi, India
2Department of Ocular Oncology and Pediatric Ophthalmology Service, Rajendra Prasad Centre for Ophthalmic Sciences, India
3Department of Physiology, Integral Health Clinic, All India Institute of Medical Sciences, New Delhi, India
4Department of HLA and Immunogenetics, AIIMS, New Delhi, India
Corresponding Author : Rima Dada
Department of Anatomy, Laboratory for molecular reproduction and genetics
All India Institute of Medical Sciences, New Delhi, India
Tel: 011 2658 8700
E-mail: [email protected]
Received January 27, 2015; Accepted March 27, 2015; Published March 29, 2015
Citation: Kumar SB, Gautam S, Tolahunase M, Chawla B, Yadav RK, et al. (2015) Improvement in Sperm DNA Quality Following Simple Life Style Intervention: A Study in Fathers of Children with Non-Familial Sporadic Heritable Retinoblastoma. J Clin Case Rep 5:509. doi:10.4172/2165-7920.1000509
Copyright: © 2015 Kumar SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

 

Abstract

Introduction and objectives: Genomic integrity of gametes is important for birth of healthy offspring. As compared to ova the sperm is more susceptible to mutation due to limited DNA damage detection and repair mechanism. Life style habits adopted by father before conception may adversely affect genomic DNA integrity in male gametes. Oxidative stress damages sperm nuclear and mitochondrial DNA. Complementary and alternative medical therapies such as yoga/meditation are being increasingly used as adjuncts to modern medicine in treatment of several clinical conditions. Therefore, in this pilot study, we analyzed the effects of yoga and meditation on seminal oxidative stress and sperm DNA integrity in fathers of children with non-familial sporadic heritable retinoblastoma (Rb) after intervention (3 and 6 months).

Methods: A total of 10 men (father of children with sporadic non-familial Rb) were recruited in this study. Semen samples were collected at base line (day 0), 3 months and after 6 months of yoga practice. Reactive oxygen species (ROS), DNA fragmentation index (DFI) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels were estimated at day 0.3 months and 6 months interval.

Results: There was reduction in mean DFI levels [p>0.05] at 3 months and 6 months [p<0.05] compared to base line level (day 0). Seminal mean ROS levels were significantly reduced after 3 months [p<0.05] and 6 months [p<0.01]. We also observed reduction in levels of 8-OHdG both after 3 months [p>0.05] 6 months [p<0.05] with respect to the base line levels (day 0).

Conclusions: Yoga/meditation significantly lowers oxidative stress and oxidative nuclear DNA damage, and levels of the mutagenic base 8OHdG. Thus yoga and meditation are simple life style interventions which are therapeutic for maintaining/restoring sperm DNA integrity

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords