alexa Improving Longevity with Metadichol<sup>and#174;</sup> by Inhibiting the BCAT1 Gene | OMICS International | Abstract
ISSN: 2329-8847

Journal of Aging Science
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Research Article

Improving Longevity with Metadichol® by Inhibiting the BCAT1 Gene

PR Raghavan*

Nanorx Inc, PO Box 131, Chappaqua, NY 10514, USA

*Corresponding Author:
PR Raghavan
Nanorx Inc, PO Box 131, Chappaqua, NY 10514, USA
E-mail: [email protected]

Received Date: February 10, 2017; Accepted Date: March 10, 2017; Published Date: March 13, 2017

Citation: Raghavan PR (2017) Improving Longevity with Metadichol® by Inhibiting the BCAT1 Gene. Aging Sci 5:174. doi: 10.4172/2329-8847.1000174

Copyright: © 2017 Raghavan PR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Metadichol® [1] is a Nanoemulsion of long-chain alcohols found in many foods. It is commonly called Policosanol and is present in foods such as rice, sugar cane, wheat, peanuts Metadichol acts as an inverse agonist on Nuclear Vitamin D receptors (VDR) that are present in cells throughout the body to stimulate the immune system and affects many biologIcal processes to modulate many diseases.

Branched-chain amino acid transferase (BCAT1) catalyzes the reversible transamination of leucine, isoleucine, and valine branched-chain amino acids (BCAA) to their respective alpha-keto acids, liberating L-glutamate. When this gene is inhibited, the amino acid chains accumulated in the tissue triggering longevity in the nematodes. The health and longevity of the nematodes improved when BCAT1 was inhibited. Gabapentin has been shown to inhibit BCAT1, but IC50 is 10000 uM. Metadichol® inhibits BCAT1 with an IC50 of 3.3 um, 3000 times more potent than Gabapentin.

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