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ISSN: 2155-6180

Journal of Biometrics & Biostatistics
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  • Research Article   
  • J Biom Biostat 2019, Vol 10(2): 430

Improving the t-SNE Algorithms for Cytometry and Other Technologies: Cen-Se' Mapping

Charles Bruce Bagwell*, Christopher M Bray, Donald J Herbert, Beth L Hill, Margaret S Inokuma, Gregory T Stelzer and Benjamin C Hunsberger
Verity Software House, Topsham, ME, USA
*Corresponding Author : Charles Bruce Bagwell, Founder of Verity Software House, POB 247 Topsham, ME 04086, USA, Tel: 2077296767, Email: [email protected]

Received Date: Apr 19, 2019 / Accepted Date: May 13, 2019 / Published Date: May 20, 2019

Abstract

SNE methods are a set of 9 to 10 interconnected algorithms that map high-dimensional data into low-dimensional space while minimizing loss of information. Each step in this process is important for producing high-quality maps. Cense′™ mapping not only enhances many of the steps in this process but also fundamentally changes the underlying mathematics to produce high-quality maps. The key mathematical enhancement is to leverage the Cauchy distribution for creating both high-dimensional and lowdimensional similarity matrices. This simple change eliminates the necessity of using perplexity and entropy and results in maps that optimally separate clusters defined in high-dimensional space. It also eliminates the loss of cluster resolution commonly seen with t-SNE with higher numbers of events. There is just one free parameter for Cen-se′ mapping, and that parameter rarely needs to change. Other enhancements include a relatively low memory footprint, highly threaded implementation, and a final classification step that can process millions of events in seconds. When the Cen-se′ mapping system is integrated with probability state modeling, the clusters of events are positioned in a reproducible manner and are colored, labeled, and enumerated automatically. We provide a step-by-step, simple example that describes how the Cen-se′ method works and differs from the t-SNE method. We present data from several experiments to compare the two mapping strategies on high-dimensional mass cytometry data. We provide a section on information theory to explain how the steepest gradient equations were formulated and how they control the movement of the low-dimensional points as the system renders the map Since existing implementations of the t-SNE algorithm can easily be modified with many of these enhancements, this work should result in more effective use of this very exciting and far-reaching new technology.

Keywords: Stochastic nearest-neighbor; High-Dimensional mapping; Dimensionality reduction

Citation: Bagwell CB, Bray CM, Herbert DJ, Hill BL, Inokuma MS, et al. (2019) Improving the t-SNE Algorithms for Cytometry and Other Technologies: Cen-Se′ Mapping. J Biom Biostat 10: 430.

Copyright: © 2019 Bagwell CB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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