alexa In ovo and Dietary Supplementation of Probiotics Affect
ISSN 2476-1966

Journal of Immunobiology
Open Access

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Research Article

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

Chasity M Pender1, Sungwon Kim1, Lindsay H Sumners1, Miranda M Ritzi1, Mark Young2 and Rami A Dalloul1*

1Avian Immunobiology Laboratory, Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA

2Star-Labs/Forage Research Inc., Clarksdale, MO, USA

*Corresponding Author:
Rami A Dalloul
Avian Immunobiology Laboratory, Department of Animal and Poultry Sciences
Virginia Tech, Litton-Reaves Hall #3170, 175 West Campus Drive, Blacksburg, VA 24061, USA
Tel: 5402310633
Fax: 5402313010
E-mail: [email protected]

Received date: June 05, 2017; Accepted date: July 05 25, 2017; Published date: July 10, 2017

Citation: Pender CM, Kim S, Sumners LH, Ritzi MM, Young M, et al. (2017) In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks. J Immuno Biol 2:126. doi: 10.4172/2476-1966.1000126

Copyright: © 2017 Pender CM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

During the first week post-hatch, the neonatal chick is immunologically vulnerable and subject to infectious threats found in the environment. Probiotics are live, non-pathogenic microorganisms known to have a positive effect on the host by improving the natural balance of gut microbiota and promoting animal health. The objective of this study was to determine the effects of administering probiotics in ovo and in the diet on broiler chick hatchability, and post-hatch immune organ weights and ileal immune-related gene expression. At embryonic day 18, 1584 eggs were injected with nothing (Dry), 1 × 106, or 1 × 107 (P1 and P2 respectively) probiotic bacteria. The remaining 393 eggs were left non-injected to serve as a negative control. Immune organ weights and tissue samples were taken on DOH and d4, 6, 8, 14, and 20. No differences were observed for hatchability or relative bursa weights. Only on d6, the P2 birds receiving the probiotic-supplemented diet had larger spleens as a result of a 2-way interaction between in ovo treatment and post-hatch diet. Both in ovo and dietary administration of probiotics were able to modulate the expression of the immune-related genes in the ileum; however, expression patterns differed based on the gene, treatment, and time point evaluated. In conclusion, these results indicate that in ovo supplementation of this commercial probiotic product does not influence hatchability and is capable of differentially modulating expression of certain genes in the ileum. Furthermore, in ovo administration of probiotics has an effect similar to that of dietary supplementation endorsing its usage to potentially promote early colonization of beneficial bacteria to stimulate intestinal and immune system development.

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