In Search of a New Screening Test for Osteoarthritis - Is Urinary Nitrate the Answer?
|Mukesh Tiwari* and Vikram Khanna|
|Department of Orthopaedics, National Institute of Medical Sciences, Jaipur, India|
|*Corresponding Author :||Mukesh Tiwari
Department of Orthopaedics
National Institute of Medical Sciences
E-mail: [email protected]
|Received: February 18, 2016 Accepted: March 21, 2016 Published: March 23, 2016|
|Citation: Tiwari M, Khanna V (2016) In Search of a New Screening Test for Osteoarthritis - Is Urinary Nitrate the Answer? J Trauma Treat 5:297. doi:10.4172/2167-1222.1000297|
|Copyright: © 2016 Tiwari M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Introduction: Even as early as 1916 it was suggested that the nitric oxide is synthetized in the mammals. This nitric oxide, synthetized in the body, was responsible for vasodilation by the endothelium derived relaxing factors and also by the stimulation of the guanylyl cyclase. Inflammatory conditions increase the production of nitrates and nitrites which is seen in the response to endotoxin and is accompanied with nitrosamine formation. Nitric oxide, hence, has been thought to be the physiological messenger and is increases in the pathological processes. This present study was conducted to find the association between the urinary secretion of nitrates and the osteoarthritis. Design: A total of 200 patients coming to the hospital out of 100 were patients with osteoarthritis of the knee joint and 100 were randomly selected. All the patients were screened for the causes of secondary osteoarthritis. Urine sample from all the patients was obtained along with X-ray of bilateral knees was taken to assess the grade of osteoarthritis. The osteoarthritic patients were assigned Group A and the randomly chosen patients were assigned the Group B. Both groups were compared and the results were evaluated. Results: In group A there were 5 cases with urinary nitrate positive as compared to 4 cases with positive urinary nitrate in group B, which was not statistically significant (p > 0.05). Conclusion: The current study clearly shows that there is no association between the urinary nitrate levels and OA.