alexa In Silico Analysis of Alkaline Shock Proteins in Enterobacteria
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

In Silico Analysis of Alkaline Shock Proteins in Enterobacteria

Seetharaaman Balaji1*, V. Murali Krishnan2
1Lecturer, Department of Biotechnology, Manipal Institute of Technology, Manipal  University, Manipal -   576104, India
2Lecturer, Department of Biochemistry, PSG College of Arts and Science, Coimbatore,India
Corresponding Author : Dr. S.Balaji, Lecturer, Department of Biotechnology
Manipal Institute of Technology, Manipal University,
Manipal - 576104, India,
Email    :  [email protected]  
Received April 20, 2008; Accepted May 15, 2008; Published May 25, 2008
Citation: Seetharaaman B, Krishnan VM (2008) In Silico Analysis of Alkaline Shock Proteins in Enterobacteria.
J Proteomics Bioinform S1: S021-S037. doi:10.4172/jpb.s1000005
Copyright: © 2008 Seetharaaman B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Alkaline shock proteins (ASPs) adapt to atypical conditions, which are categorized into a family of small proteins. Alkaline shock proteins are identified in many bacteria and they are involved in stress response. The molecular basis for the survival of bacteria under extreme conditions in which growth is inhibited is a question of great current interest. A preliminary study was carried out to determine residue pattern conservation among the alkaline shock proteins of enteric bacteria, responsible for extreme alkaline tolerance especially in Staphylococcus and Streptococcus. To decipher, is there any secret hidden in the alkaline shock proteins? Bioinformatics approach was used and the molecular evidence proved the relationship between Staphylococcus and Streptococcus with respect to ASP. The sequence, structure and phylogenetic analyses inferred the relationships of various bacteria with respect to the conserved motif (VDNNKAK) of ASPs. Automated subsystem functional annotation of 172 homologous ASPs was done for various bacteria. Currently the structure of the ASP is not available in the Protein Data Bank (PDB). Since the Staphylococcus species formed the root of the phylogenetic tree, the structure of the Staphylococcus aureus (strain bovine RF122) was modeled in order to understand further about the structure and mechanism.

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