alexa In Silico Gene Expression Based Analysis on Claudin Fam
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

In Silico Gene Expression Based Analysis on Claudin Family Members Association with Human Thyroid Cancer

Shaukat Iqbal Malik1*, Zoya Khalid2 and Sheema Sameen2

1Department of Bioinformatics, Mohammad Ali Jinnah University, Islamabad, Pakistan

2Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan

*Corresponding Author:
Shaukat Iqbal Malik
Department of Bioinformatics
Mohammad Ali Jinnah University
Islamabad, Pakistan
E-mail: [email protected]

Received Date: November 07, 2011; Accepted Date: December 05, 2011; Published Date: December 12, 2011

Citation: Malik SI, Khalid Z, Sameen S (2011) In Silico Gene Expression Based Analysis on Claudin Family Members Association with Human Thyroid Cancer. J Proteomics Bioinform 4: 278-283. doi: 10.4172/jpb.1000201

Copyright: © 2011 Malik SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Thyroid cancer is one of the major types of cancers worldwide. A large amount of effort has been put in order to find the genetic basis of this cancer. Many genes have been reported before out of which claudin family is one of the example. The claudin protein family consists of more than 20 members which are made up of key structural rudiments inside the tight junction. The association of claudin-1 with the thyroid cancer has already been predicted experimentally. In order to investigate the genetic reason of human thyroid cancer computationally, the systematic analysis of claudin gene family has been carried out. To fulfill this task the bioinformatics methodologies are combined for the assessment of claudin gene family expressions. Results obtained showed and verified the association of CLDN1 member with the thyroid cancer.


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