alexa In Silico Identification of Dual Ability of N. gonorrhoeae ddl for Developing Drug and Vaccine Against Pathogenic Neisseria and Other Human Pathogens
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

In Silico Identification of Dual Ability of N. gonorrhoeae ddl for Developing Drug and Vaccine Against Pathogenic Neisseria and Other Human Pathogens

Debmalya Barh1*, Amarendra Narayan Misra2 and Anil Kumar3

1Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India

2Department of Biosciences and Biotechnology, School of Biotechnology, Fakir Mohan University, Jnan Bigyan Vihar, Balasore-756020, Orissa, India

3School of Biotechnology, Devi Ahilya University, Khandwa Road Campus, Indore, MP-452001, India.

*Corresponding Author:
Debmalya Barh
Centre for Genomics and Applied
Gene Technology, IIOAB, Nonakuri
Purba Medinipur, WB-721172, India
Tel: +91-9449 5500 32
E-mail: [email protected]

Received Date: January 23, 2010; Accepted Date: March 14, 2010; Published Date:March 14, 2010

Citation: Barh D, Misra AN, Kumar A (2010) In Silico Identification of Dual Ability of N. gonorrhoeae ddl for Developing Drug and Vaccine Against Pathogenic Neisseria and Other Human Pathogens. J Proteomics Bioinform 3: 082-090. doi: 10.4172/jpb.1000125

Copyright: © 2010 Barh D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The transmission and prevention of gonococcal infection is a global health problem and an effective drug or vaccine against the pathogen is yet to be developed. In our previous studies by analyzing metabolic pathways and membrane proteome of N. gonorrhoeae we found that four membrane associated targets could be better option in developing anti- gonorrhoeae drugs and vaccine. Here we showed that among these putative targets, D-alanine—D-alanine ligase (ddl) is the best candidate for development of both drug and vac- cine against N. gonorrhoeae and various other human bac- terial pathogens. Using in silico approaches, we developed the 3-D model of the enzyme and potential epitopes are also identified that may be helpful in peptide vaccine develop- ment against multiple pathogens including pathogenic Neis- seria . Epitopes require experimental validation for their ef- fectiveness as peptide vaccines against these pathogens.

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