alexa In Silico Identification of Novel Glucagon Receptor Antagonist for the Treatment of Type 2 Diabetes Mellitus
ISSN: 2329-6674

Enzyme Engineering
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Research Article

In Silico Identification of Novel Glucagon Receptor Antagonist for the Treatment of Type 2 Diabetes Mellitus

Utkarsh Raj1, Yashasvi Jain2, Himansu Kumar3, Saurabh Gupta4, Rashmi Tripathi5and Pritish Kumar Varadwaj6
1Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
2Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
3Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
4Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
5Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
6Indian Institute of Information Technology-Allahabad, Allahabad-211012, UP, India
Corresponding Author : Pritish Kumar Varadwaj
Indian Institute of Information Technology
Allahabad, UP, India
Tel: 0532 292 2000
E-mail: [email protected]
Received August 25, 2015; Accepted August 28, 2015; Published August 31, 2015
Citation: Raj U, Jain Y, Kumar H, Gupta S, Tripathi R, et al. (2015) In Silico Identification of Novel Glucagon Receptor Antagonist for the Treatment of Type 2 Diabetes Mellitus. Enz Eng 4:128. doi:10.4172/2329-6674.1000128
Copyright: © 2015 Utkarsh R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Type 2 diabetes mellitus is caused mainly due to an imbalance in the relationship between glucagon and insulin levels in plasma. To counteract the actions of insulin and maintain normoglycemia during the fasting state by inducing hepatic glucose production are the major biological action of glucagon. Glucagon exerts its action through activation of the glucagon receptor (GCGR). These observations have prompted interest in blockade of GCGR activity for the control of over production of hepatic glucose or the treatment of type 2 diabetes mellitus. In the present study, a large virtual library of compounds was screened against the crystal structure of GCGR to identify a favorable therapeutic choice of GCGR antagonist. The interactions of lead compound with the active site of GCGR were analyzed and molecular dynamics study was also performed to check its stability in the receptor pocket. The proposed lead compound was also compared with some already reported GCGR antagonists for their binding affinity and other pharmacological properties. As a conclusion of this study, we have identified a compound STOCK1N82694 as potent GCGR antagonist for the treatment of type 2 diabetes mellitus.

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