alexa IN SILICO PREDICTIONS FOR MANIPULATIONS OF TESTIS SPECIFIC HEAT SHOCK PROTEIN HSP-70 GENES -HSPA2 AND HSPA1L WITH CALOTROPIS LATEX IN REGULATING MALE FERTILITY


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Research Article

IN SILICO PREDICTIONS FOR MANIPULATIONS OF TESTIS SPECIFIC HEAT SHOCK PROTEIN HSP-70 GENES -HSPA2 AND HSPA1L WITH CALOTROPIS LATEX IN REGULATING MALE FERTILITY

R.G.Hemalatha1 and 2 Dr.E. Padmini
  1. Research Scholar, Mother Teresa Women’s University, Kodaikanal- 624 102
  2. Associate Professor, PG Department of Biochemistry, Bharathi Women’s College,Chennai-600108.
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Abstract

Regulation of male fertility is needed to protect the health of the society. It is well proved that Heat Shock Proteins (HSPs) influence various aspects of reproduction wherein the expression of HSP 70 is an essential part of sperm development. We reported the spermicidal effect of the latex of the medicinal plant Calotropis. In our effort to design dual action spermicide from Calotropis, in this study, different bioinformatics tools were used to find the possible manipulations of testis specific HSP genes-HSPA2 and HSPA1L with Calotropis sp. Besides the results of Ligand-Protein docking with Arguslab software, the predictions carried out online with STRING and STITCH databases along with GNCPro Gene Central Network and Array Express would be useful in custom designing of high throughput array experiments to have guided metabolite gene network in regulating male fertility with Calotropis- HSP

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