alexa In Silico Structure Modeling and Characterization of Hy
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

In Silico Structure Modeling and Characterization of Hypothetical Protein YP_004590319.1 Present in Enterobacter aerogens

Ritika Gupta1*, Ankita Dey2, Anu Vijan3 and Bitu Gartia4

1Department of Biotechnology, Meerut Institute of Engineering and Technology (MIET), Meerut, India

2Department of Biotechnology, Haldia Institute of Technology, West Bengal, India

3University Institute of Biotechnology, Chandigarh University, Punjab, India

4School of Biotechnology, KIIT University, Bhubaneswar, India

*Corresponding Author:
Ritika Gupta
Department of Biotechnology
Meerut Institute of Engineering and Technology (MIET)
Meerut, India
Tel: +91 9703896342
E-mail: [email protected]

Received Date: May 12, 2017; Accepted Date: May 31, 2017; Published Date: June 02, 2017

Citation: Gupta R, Dey A, Vijan A, Gartia B (2017) In Silico Structure Modeling and Characterization of Hypothetical Protein YP_004590319.1 Present in Enterobacter aerogens. J Proteomics Bioinform 10:152-170. doi: 10.4172/jpb.1000436

Copyright: © 2017 Gupta R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Transfer RNAs anticodon post-transcriptional modifications are responsible to the high fidelity of protein synthesis. In eubacteria, two genome-encoded transfer RNA (tRNA) species bear the same CAU sequence as the anticodons, which are differentiated by modified cytidines at the wobble positions. We have determined the structure model of the hypothetical protein. The structure unexpectedly reveals an idiosyncratic RNA helicase module fused with a GCN5-related N-acetyltransferase (GNAT) fold, which intimately cross interact. The stereo chemical quality of the protein model was checked by using in silico analysis with SWISS- MODEL, PyMol, PROCHECK, ProSA and QMEAN servers. These results may be helpful for further investigations for determining crystal structure of the hypotheitical protein and developing target molecules to inhibit Enterobacter aerogenes.

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