alexa In the Emergency Department, Are Serum Biomarkers useful to Screen Independent Frail Seniors Exposed to Future Functional Decline or Mobility Impairments after a Minor Injury?| Abstract
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
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  • Research Article   
  • J Gerontol Geriatr Res 2017, Vol 6(6): 457
  • DOI: 10.4172/2167-7182.1000457

In the Emergency Department, Are Serum Biomarkers useful to Screen Independent Frail Seniors Exposed to Future Functional Decline or Mobility Impairments after a Minor Injury?

Mélissa Blouin1*, Marie-Josée Sirois1,2,3, Mylène Aubertin-Leheudre4,5, Lauren E Griffith6, Linda Nadeau1, Raoul Daoust7, Jacques Lee8 and Marcel Émond1,2,9,10
1Centre de recherche du CHU de Québec-Université Laval, santé des populations et pratiques optimales en santé, , Québec, Canada
2Center of Excellence on Aging, , Québec, Canada
3Faculty of Medicine, Department of Rehabilitation, Laval University, Québec, Canada
4Department of Physical Activity Sciences, Université du Québec à Montréal, , Québec, Canada
5Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, , Montréal, Québec, Canada
6Department of Health Research Methods, Evidence, and Impact, McMaster University, Ontario, Canada
7Hôpital du Sacré-Coeur de Montréal, , Québec, Canada
8Sunnybrook Health Sciences Centre, , Ontario, Canada
9Faculty of Medicine, Department of Family Medicine and Emergency Medicine, Laval University, Québec, Canada
10Centre de recherche sur les soins et les services de première ligne de l’Université Laval, , Québec, Canada
*Corresponding Author : Mélissa Blouin, Centre de recherche du CHU de Québec-Université Laval, Axe santé des populations et pratiques optimales en santé, Québec, Canada, Tel: 418-649-0252, Exn. 66024, Fax: 418-649-5733, Email: [email protected]

Received Date: Dec 22, 2017 / Accepted Date: Dec 28, 2017 / Published Date: Dec 29, 2017

Abstract

Background: Frailty is a geriatric syndrome conferring a high risk of declining functional capacities. Some serum biomarkers are associated with frailty, but no study has specifically investigated the possible association between frailty and serum biomarkers in independent community-dwelling seniors who consulted the emergency department (ED) following a minor injury.
Objective: 1) To explore baseline associations between six serum biomarkers and the frailty status of independent community-dwelling seniors who were seen in the ED for minor injuries, 2) to determine if ED serum biomarker assay combined with frailty status improves the prediction of 3-month functional decline or mobility impairments in this population, beyond frailty status alone.
Methods: The study includes 190 participants (age ≥ 65 years, independent in daily activities and discharged home). Biomarkers were obtained at baseline from blood samples and values were identified as “normal” or “at risk”. Seniors were classified as “robust” or “pre-frail/frail” according to the CHSA-CFS and SOF scales. The seniors were screened for frailty at baseline (ED visit) while their functional status (OARS scale) and mobility characteristics (less than 5 outings/week and fear of falling) were assessed at the ED visit and three months later.
Results: When compared to robust, a greater proportion of pre-frail/frail seniors had at-risk creatinine levels (p=0.02) at baseline. All the other biomarkers were not significant. In the prospective analysis, we found that having at least one at-risk biomarker slightly increased the prediction of 3-month mobility impairments in robust seniors (RR:0.44[0.10-1.91]). However, ED frailty status clearly remained the stronger predictor of future mobility impairments in pre-frail/frails having normal biomarkers (RR:3.11(0.98-9.84), p=0.007). Results were not significant for prospective functional decline.
Conclusion: ED biomarker assays are not useful in predicting 3-month functional decline or mobility impairments beyond what is predicted by frailty status alone in independent community-dwelling seniors who consulted for minor injuries.

Keywords: Frailty; Serum biomarkers; Emergency department; Minor injury; Functional decline; Mobility decline; Seniors

Citation: Blouin M, Sirois M, Aubertin-Leheudre M, Griffith LE, Nadeau L, et al. (2017) In the Emergency Department, Are Serum Biomarkers useful to Screen Independent Frail Seniors Exposed to Future Functional Decline or Mobility Impairments after a Minor Injury? J Gerontol Geriatr Res 6: 457. Doi: 10.4172/2167-7182.1000457

Copyright: © 2017 Blouin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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