alexa In Vitro Activity Screening of Snake Venom against Multi Drug Resistant Tuberculosis
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Short Communication

In Vitro Activity Screening of Snake Venom against Multi Drug Resistant Tuberculosis

Sujay Kumar Bhunia1, Mrinmoy Sarkar1, Sananda Dey1, Arpita Bhakta2, Antony Gomes3 and Biplab Giri1*

1Experimental Medicine & Stem Cell Research Laboratory, Department of Physiology, West Bengal State University, Barasat, Kolkata 700 126, India

2Department of Laboratory Medicine, AMRI Hospital, Goriahat Road, Kolkata 700 031, India

3Laboratory of Toxicology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92 APC Road, Kolkata 700 009, India

*Corresponding Author:
Biplab Giri
Experimental Medicine & Stem Cell Research Laboratory
Department of Physiology
West Bengal State University,
Barasat Kolkata 700 126, India
Tel/Fax: 91 33-2524 1977
E-mail: [email protected]

Received Date: November 15, 2015; Accepted Date: December 08, 2015; Published Date: December 15, 2015

Citation: Bhunia SK, Sarkar M, Dey S, Bhakta A, Gomes A, et al. (2015) In Vitro Activity Screening of Snake Venom against Multi Drug Resistant Tuberculosis. J Trop Dis 4:192. doi:10.4172/2329-891X.1000192

Copyright: © 2015 Bhunia SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..

 

Abstract

The re-emergence of multidrug-resistant tuberculosis (MDR-TB) events has brought to light the importance of screening effective novel drugs. In the present study, in vitro activities of different snake (Naja naja, Bungarus fasciatus, Daboia russelli russelli, Naja kaouthia) venoms have been investigated against clinical isolate of MDR-TB strains. All the venoms inhibited the mycobacterial growth for at least a week in common and two of them (Naja naja, Naja kaouthia) showed significantly longer inhibition up to two weeks against the MDR-TB strain with single dose and one repetition of those two venoms exhibited inhibition up to more than 4 weeks.

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