alexa In Vitro and in Vivo Antidiabetic Activity of Rumex Ves
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

In Vitro and in Vivo Antidiabetic Activity of Rumex Vesicarius Leaves Extract in Streptozotocin Induced Diabetic Albino Wister Rats

Reddy NS*, Sabbani V and Choday V

Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author:
Reddy NS
Department of Pharmacology
Vishnu Institute of Pharmaceutical Education and Research
Vishnupur, Narsapur, Medak, Telangana, India
Tel: +919491229728
E-mail: [email protected]

Received date: April 03, 2017; Accepted date: June 06, 2017; Published date: June 12, 2017

Citation: Reddy NS, Sabbani V, Choday V (2017) In Vitro and in Vivo Antidiabetic Activity of Rumex Vesicarius Leaves Extract in Streptozotocin Induced Diabetic Albino Wister Rats. J Diabetes Metab 8:745. doi: 10.4172/2155-6156.1000745

Copyright: © 2017 Reddy NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: The principle goal of this work is to assess the in vitro and in vivo antidiabetic activity of ethanolic extract of Rumex vesicarius in the streptozotocin actuated diabetic rats. Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes in albino rats. The induction of diabetes was confirmed after 3 days of streptozotocin injection and rats with fasting blood glucose levels were greater than 200 mg/dl and were considered to be diabetic used in the experiment. Rumex vesicarius at a once daily dose of 100 mg/kg, 200 mg/kg and 400 mg/kg along with Glibenclamide 10 mg/kg was also given for 1 week. On the last day, the blood was collected from all groups of rats which have fasted overnight by puncturing the retro-orbit of the eye under mild ether anesthetic condition. Results: The statistical data indicated that the different doses of Rumex vesicarius significantly decrease the level of blood glucose in streptozotocin induced rats. This result indicated that Rumex vesicarius can protect pancreatic β-cells from streptozotocin induced damage which is confirmed by the results of histopathological examination of pancreas. Conclusion: Our investigation has clearly indicated that ethanolic extract of Rumex vesicarius showed antihyperglycemic activity due to its possible systemic effect involving in pancreatic mechanism.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version