In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and CefepimeShomita Ferdous1,2*, Md Zakir Sultan1, Tafsir Bashar1, Asma Rahman3 and Md Saiful Islam1
- *Corresponding Author:
- Shomita Ferdous
Department of Clinical Pharmacy and Pharmacology
Faculty of Pharmacy, University of Dhaka
Tel: +880 2-8614150
E-mail: [email protected]
Received date: January 25, 2015; Accepted date: March 03, 2015; Published date: March 10, 2015
Citation: Ferdous S, Sultan MZ, Bashar T, Rahman A, Islam MS (2015) In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and Cefepime. Pharm Anal Acta 6:348. doi: 10.4172/2153-2435.1000348
Copyright: © 2015 Ferdous S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A diabetic individual gradually becomes more prone to infections and can be prescribed Metformin concurrently with a broad spectrum antibiotic like Cefepime. Our research examines the possibility of drug-drug interaction between Metformin and Cefepime in a number of in vitro and in vivo parameters. The in vitro tests including Differential Scanning Calorimeter, Scanning Electron Microscope and Fourier Transform Infra Red analysis were found to reveal visible changes in melting points, morphological structures and rearrangement of functional groups due to the interaction. The disc diffusion method was used to compare the antimicrobial properties of all the test samples and the antimicrobial potential of Cefepime was found to be suppressed moderately after in vitro interaction with Metformin. The alteration of the in vivo antidiabetic activity of Metformin was evaluated in streptozotocin-induced Long-Evans Rats, and the anti-hyperglycemic effect of Metformin was detected to decrease significantly in the resulting product of this interaction.