alexa In Vitro Antileishmanial Activity of Helianthus annuus
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

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Research Article

In Vitro Antileishmanial Activity of Helianthus annuus and Pulicaria crispa (Asteraceae)

Mohamed M1*, Ahmed MM2, Elwaleed EH3, Walaa SE2 and Mahgoub SE3

1Department of Pharmacognosy, Faculty of Pharmacy, International University of Africa, Sudan

2Department of Immunology and Clinical Pathology, Institute of Endemic Diseases, University of Khartoum, Sudan

3Department of Pharmacognosy, Faculty of Pharmacy, Omdurman Islamic University, Sudan

*Corresponding Author:
Mohamed Mirghani
Department of Pharmacognosy, Faculty of Pharmacy
International University of Africa, Sudan
Tel: +249123854142
E-mail: [email protected]

Received Date: April 23, 2017; Accepted Date: May 03, 2017; Published Date: May 08, 2017

Citation: Mohamed M, Ahmed MM, Elwaleed EH, Walaa SE, Mahgoub SE (2017) In Vitro Antileishmanial Activity of Helianthus annuus and Pulicaria crispa (Asteraceae). Nat Prod Chem Res 5:268. doi: 10.4172/2329-6836.1000268

Copyright: © 2017 Mohamed M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Leishmaniasis which is a neglected tropical disease is a global health problem. The treatment options are limited. They are either toxic or expensive. This study was conducted to test some medicinal plants belonging to Asteraceae family against Leishmania donovani promastigotes. Five plants have been selected: Helianthus annuus leaves, Pulicaria crispa aerial parts, Geigeria alata aerial parts, Acanthospermum hispidum aerial parts and Sonchus oleraceus leaves. H. annuus and P. crispa petroleum ether and chloroform extracts showed significant antileishmanial activity at 50 μg/mL in the general screening test, whereas the other three plant extracts showed significant antileishmanial activity in only one solvent system. H. annuus and P. crispa were further tested at doses range of 50, 25, 12.5, 6.25 and 3.125 μg/mL. The IC50 for petroleum ether and chloroform extracts of H. annuus were 4.5 and 3 μg/mL respectively. While the IC50 for petroleum ether and chloroform extracts of P. crispa were 4.9 and 3.75 μg/mL respectively. Thin layer chromatography for the active extracts of H. annuus and P. crispa has revealed the high similarity in their chemical composition which explains the similarity of their antiparasitic activity.

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