alexa In Vitro Dissolution Study and Assay of Diclofenac Sodi
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

In Vitro Dissolution Study and Assay of Diclofenac Sodium from Marketed Solid Dosage form in Bangladesh

Tania Sultana1,2, Md. Didaruzzaman Sohel1,2*, Md. Hassan Kawsar1 and Rebecca Banoo3

1Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

2Incepta Pharmaceuticals Ltd., Dhaka, Bangladesh

3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

*Corresponding Author:
Md. Didaruzzaman Sohel
Department of Pharmacy
State University of Bangladesh, Dhaka, Bangladesh
Tel: +8801916016974
E-mail: [email protected]

Received Date: April 01, 2017; Accepted Date: April 26, 2017; Published Date: May 05, 2017

Citation: Sultana T, Sohel MD, Kawsar MH, Banoo R (2017) In Vitro Dissolution Study and Assay of Diclofenac Sodium from Marketed Solid Dosage form in Bangladesh. J Bioanal Biomed 9:118-122. doi: 10.4172/1948-593X.1000164

Copyright: © 2017 Sultana T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of this study is to determine the potency of drug available in our market in Bangladesh. Diclofenac Sodium is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) and that are widely used and it is an Over the Counter (OTC) drug in Bangladesh. Potency determination was performed to evaluate that the marketed sample comply with the declared specification or not. In vitro Dissolution study was performed to see that if potency is high but the drug is not bioavailable. Hardness is also checked to see that whether it interfere with the dissolution which ultimately effect the bioavailability. In this present study a simple, cost effective and spectrophotometric method for the potency determination of marketed Diclofenac Sodium tablets is used. Four samples were randomly collected from the market and coded as D01, D02, D03 and D04 and the potency determined are 99.30%, 103.38%, 98.22% and 102.16% respectively. Hardness and in vitro dissolution of the above four brands of Diclofenac Sodium tablets were also studied and reported in the paper. After 1 h Dissolution release of DO1, D02, D03 and D04 are 94.16%, 93.97%, 96.94% and 98.5% respectively. From all of the studies it seems that the samples were collected complies with the BP and USP requirements.

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