alexa In vitro Effects of Salicylic Acid on Plasma Paraoxonase 1 Activity
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Research Article

In vitro Effects of Salicylic Acid on Plasma Paraoxonase 1 Activity

Dhouha Haj Mouhamed1,2*, Asma Ezzaher1,2, Lotfi Gaha2, Wahiba Douki1,2 and Mohamed Fadhel Najjar1

1Laboratory of Biochemistry-Toxicology, Monastir University Hospital, Monastir 5000, Tunisia

2Research Laboratory “Vulnerability to Psychotic disorders LR 05 ES 10”, Department of Psychiatry, Monastir University Hospital, Tunisia

*Corresponding Author:
Dhouha Haj Mouhamed
Laboratory of Biochemistry-Toxicology
University Hospital of Monastir 5000, Tunisia
Tel: (216) 73106000
Fax: (216) 73460678
E-mail: [email protected]

Received date: February 12, 2013; Accepted date: April 04, 2013; Published date: April 07, 2013

Citation: Mouhamed DH, Ezzaher A, Gaha L, Douki W, Najjar MF (2013) In vitro ffects of Salicylic Acid on Plasma Paraoxonase 1 Activity. J Drug Metab Toxicol 4:148. doi: 10.4172/2157-7609.1000148

Copyright: © 2013 Mouhamed DH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: Our study aimed to examine the effects of salicylic acid on paraoxonase activity in healthy volunteers.
Methods: Plasma from healthy volunteers was spiked with salicylic acid drug. The working solutions were then diluted with plasma to obtain concentrations that covered the therapeutic margin. Specimens were incubated at 25 and 37°C, and we measured PON1 activities in the presence of different drug concentrations after 1 h, 3 h, and 24 h and after one week.
Results: After incubation in vitro, a significant increase of paraoxonase 1 activity according to salicylic acid concentration and incubation duration, regardless of temperature incubation was showed. This increase was marked especially after 24 h of incubation. The stimulatory effect of salicylic acid is concentration and incubation durationdependent and does not seem to be related to temperature incubation.
Conclusion: The tested Salicylic acid significantly stimulated PON1 activity in a concentration dependent manner. This result shows that acetyl salicylic acid treatments have a beneficial effect dose and time dependent that may contribute to prevent atherosclerosis.


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