alexa In vitro Fertilization with Mouse Sperm Activated by Co
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

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Review Article

In vitro Fertilization with Mouse Sperm Activated by Components of Licorice Root Extract

Nguyen Huu Tung1,4, Hiromitsu Tanaka1, Akira Tsujimura2, Yasushi Miyagawa3, Morimasa Wada1, Shunsuke Fujii1, Takuhiro Uto1 and Yukihiro Shoyama1*
1Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan
2Department of Urology, Juntendo University Hospital, Japan
3Department of Urology, Graduate School of Medicine, Osaka University, Japan
4School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam
*Corresponding Author : Yukihiro Shoyama
Faculty of Pharmaceutical Sciences
Nagasaki International University, 2825-7 Huis Ten Bosch
Sasebo, Nagasaki 859- 3298, Japan
Tel: +81956205622
E-mail: [email protected]
Received March 08, 2016; Accepted April 18, 2016; Published April 24, 2016
Citation: Tung NH, Tanaka H, Tsujimura A, Miyagawa Y, Wada M, et al. (2016) In vitro Fertilization with Mouse Sperm Activated by Components of Licorice Root Extract. Nat Prod Chem Res 4:217. doi:10.4172/2329-6836.1000217
Copyright: © 2016 Tung NH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Licorice (Glycyrrhiza species) is an important natural product that is frequently used in traditional Chinese medicine. In this review article, we discuss the quality control of licorice using monoclonal antibodies against the licorice components glyzyrrhizin (GC) and liquiritin (Liq); the monitoring of licorice extract activity using an assay system in mice; and the isolation of two active phenolic components, isolitiritigenin and formononetin, and their effectiveness for improving in vitro fertilization in mice. Finally, we present the outstanding questions and potential applications of licorice root extract.

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