alexa In Vitro Oxidative Damage Induced in Livers, Hearts and Kidneys of Rat Treated with Water Extract (Leachate) from Municipal Battery Recycling Site: Evidence as Environmental Pollution and Tissue Damage
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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Research Article

In Vitro Oxidative Damage Induced in Livers, Hearts and Kidneys of Rat Treated with Water Extract (Leachate) from Municipal Battery Recycling Site: Evidence as Environmental Pollution and Tissue Damage

Akintunde J. K*, and Oboh G

Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory, Department of Biochemistry,Federal University of Technology, P.M.B., 704, Akure 340001, Nigeria.

*Corresponding Author:
Akintunde J.K
Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory
Department of Biochemistry, Federal University of Technology
P.M.B., 704, Akure 340001, Nigeria
Tel: +23408064156056
Fax: +23407031388644
E-mail: [email protected]

Received date: August 24, 2012; Accepted date: September 27, 2012; Published date: October 01, 2012

Citation: Akintunde JK, Oboh G (2012) In Vitro Oxidative Damage Induced in Livers, Hearts and Kidneys of Rats Treated with Leachate from Battery Recycling Site: Evidence for Environmental Contamination and Tissue Damage . J Clin Exp Pathol 2:129. doi:10.4172/2161-0681.1000129

Copyright: © 2012 Akintunde JK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Abstract
The health effects of the Municipal Auto-Battery Dust Leachate (MABDL) and Elewi Odo Municipal Auto-
Battery Recycling Site Leachate (EOMABRL) on levels of Thiobarbituric Acid Reactive Substances (TBARS) were
investigated in livers, kidneys and hearts of male albino rat-in vitro. The two varieties of leachates significantly
(p<0.05) increased MDA level in the liver, kidney and heart in a dose-dependent manner with Municipal Auto-Battery
Dust Leachate (MABDL) having stronger induction ability than Elewi Odo Municipal Auto-Battery Recycling Site
Leachate (EOMABRL). MDA levels of EOMABRL were significantly (p<0.05) elevated in the liver, kidney and heart
by 55.56%, 41.3% and 39.13% respectively compared to the corresponding control at the highest dose. Similarly,
MDA contents of MABDL were significantly (p<0.05) elevated in the kidney, heart and liver by 195.65%, 115.2% and
83.33% respectively compared to the corresponding control at the highest dose. However, the liver is highly sensitive
to EOMABRL exposure than kidney and heart. In contrast, the kidney is more susceptible to MABDL exposure than
heart and liver. Collectively, the possible mechanisms by which varieties of battery leachates exert nephritis, hepatitis
and cardiovascular malfunctioning is through high induction of lipid peroxidation and heavy metal (Cu2+ ,Fe2+ ,Pb2+ etc)
catalyzed hydrogen peroxide decomposition to produced OH• via Fenton reaction.

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