alexa <em>In Vitro</em> Protease Inhibition, Modulation of PLA2 Activity and Protein Interaction Studies of <em>Calotropis gigantea</em> | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

In Vitro Protease Inhibition, Modulation of PLA2 Activity and Protein Interaction Studies of Calotropis gigantea

DSVGK Kaladhar1*, Govinda Rao Duddukuri1, Ramesh K1, Varahalarao Vadlapudi2 and Nagendra Sastry Yarla1
1Department of Biochemistry/Bioinformatics, GITAM University, Visakhapatnam, AP, India
2Department of Biochemistry, Dr. Lankapalli Bullayya P G College, Visakhapatnam-530013, AP, India
Corresponding Author : DSVGK Kaladhar
Department of Biochemistry/Bioinformatics
GITAM University
Visakhapatnam, AP, India
Tel: +91-9885827025
E-mail: [email protected]
Received: July 25, 2013; Accepted: September 23, 2013; Published: September 30, 2013
Citation: DSVGK Kaladhar, Duddukuri GR, Ramesh K, Vadlapudi V, Yarla NS (2013) In Vitro Protease Inhibition, Modulation of PLA2 Activity and Protein Interaction Studies of Calotropis gigantea. J Clin Cell Immunol 4:165. doi:10.4172/2155-9899.1000165
Copyright: © 2013 DSVGK Kaladhar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Plant protection strategies have been proven to be the most promising approach on selection of protease inhibitors. Protease inhibition and PLA2 activity of white and violet varieties of Calotropis gigantea L., has been studied. Comparative protease inhibition studies on white and violet varieties have shown small variation in protease inhibition. In trypsin inhibition, white variety has not shown inhibition but the violet variety has shown the inhibition at 10 μl concentration. In Protease K inhibition, white variety has not shown inhibition but the violet variety has shown the inhibition at 10 μl and 5 μl concentrations respectively. In Chymotrypsin inhibition, both white and violet varieties have not shown any protease inhibition. The plant has also exhibited PLA2 inhibition activity in blood agar containing egg yolk. Protein interaction network profile has shown interactions with circulatory, neural and immune system components that can modulate and simulate the mechanism in the system approach.

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