alexa <em>In Vivo</em> Confocal Microscopy: A Promising Diagnostic Method for Cutaneous Oncology | OMICS International | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Review Article

In Vivo Confocal Microscopy: A Promising Diagnostic Method for Cutaneous Oncology

Juliana Casagrande Tavoloni Bragaa1, Theresa Caob2, Margaret C. Olivierob2, João Duprata1, Harold S. Rabinovitzb2 and Gisele Gargantini Rezzea1*

1Department of Cutaneous Oncology, Hospital AC Camargo, São Paulo, SP, Brazil

2Skin and Cancer Associates, Plantation, Florida, USA

*Corresponding Author:
Gisele Gargantini Rezze
Rua Prof. Antonio Prudente, 211
Sao Paulo, SP, Brazil, CEP 01509-900
Tel: 551182024904
Fax: 551131205045
E-mail: [email protected]

Received date: October 18, 2011; Accepted date: March 12, 2012; Published date: March 16, 2012

Citation:Tavoloni Bragaa JC, Caob T, Olivierob MC, Duprata J, Rabinovitzb HS, et al. (2012) In Vivo Confocal Microscopy: A Promising Diagnostic Method for Cutaneous Oncology. J Clin Exp Dermatol Res S3:002. doi: 10.4172/2155-9554.S3-002

Copyright: © 2012 Tavoloni Bragaa JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Confocal microscopy enables the acquisition of non-invasive microscopic images with real-time visualization of nuclear and cellular morphologies in vivo, which is analogous to histological imaging at high magnification. Thus, this tool has become useful in the diagnosis of melanoma and non-melanoma cutaneous tumors. The resulting images are oriented parallel to the surface of the skin (transverse sections), which is the major difference compared to conventional histology. The fact that confocal microscopy images the tissue in the horizontal plane, similar to dermoscopy, and provides high magnification with a cellular resolution that is similar to that of histopathology, makes this technique an important area of clinical research in evaluating skin cancer. The objective of the article is to describe this technique and its primary diagnostic findings for different types of skin cancer.


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