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Research Article
In Vivo Safety of Aqueous Extracts of Maytemus putterlickoides, Senna spectabilis and Olinia usambarensis on Mice Models
Mugweru FG*, Nyamai DW, Arika WM, Mworia JK, Ngugi MP, Njagi ENM and Ngeranwa JJN
Department of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Kenya
- *Corresponding Author:
- Francis Mugweru Gitau
Department of Biochemistry and Biotechnology
Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya
Tel: +254721236674
E-mail: [email protected]
Received date: March 21, 2016; Accepted date: May 04, 2016; Published date: May 11, 2016
Citation: Mugweru FG, Nyamai DW, Arika WM, Mworia JK, Ngugi MP, et al. (2016) In Vivo Safety of Aqueous Extracts of Maytemus putterlickoides, Senna spectabilis and Olinia usambarensis on Mice Models. J Clinic Toxicol 6:305. doi:10.4172/2161-0495.1000305
Copyright: © 2016 Mugweru FG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Plant products are used as the primary health care in developing countries due to their availability and affordability compared to conventional methods. It is estimated that more than 80% of the world’s population use herbal preparations in the management and treatment of diseases. Herbal products are now readily available in supermarkets and drug stores. The therapeutic value of these herbal products is believed to be due to the presence of bioactive elements present in the plant parts. Toxicity studies should, however be carried to ascertain the safety of the herbal preparation. In this study, safety studies were carried out through biochemical assays, histopathology and hematological tests. The plant extracts led to changes in body weight, hematological and histopathological changes like increase in lymphocyte number. High dose of orally administered Olinia usambarensis also caused microcytic hypochromic anemia. Senna spectabilis and Olinia usambarensis revealed intense infiltration of inflammatory cells causing necrosis and loss of cellular details of the kidney. This study will enhance understanding of the safety of ethno-medical materials in the management of diarrhea caused by bacterial pathogens.
