Inappropriate Use of Antimicrobials and the Determinants among Patients Hospitalized in 3 Hospitals (Mizan, Bonga and Tepi) in Southwest EthiopiaTadele Mekuriya Yadesa*
Department of Pharmacy, College of Medicine and Health Science, Ambo University, Ambo, Ethiopia
- *Corresponding Author:
- Tadele Mekuriya Yadesa
Lecturer and Clinical Pharmacy Specialist
Department of Pharmacy, College of Medicine and Health Science
Ambo University, Ambo, Ethiopia
E-mail: [email protected]
Received date: February 15, 2017; Accepted date: February 22, 2017; Published date: February 28, 2017
Citation: Yadesa TM (2017) Inappropriate Use of Antimicrobials and the Determinants among Patients Hospitalized in 3 Hospitals (Mizan, Bonga and Tepi) in Southwest Ethiopia. J Bioanal Biomed 9:073-079. doi: 10.4172/1948-593X.1000157
Copyright: © 2017 Yadesa TM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The spread of antimicrobial resistance in developing countries is associated with complex and interconnected factors. Accordingly, there is poor controlling system in use of all the available antimicrobials in the hospital. This facilitates for the spread of inappropriateness of prescribing ending up with emergence and spread of antimicrobial resistance.
Objective: The study aims to assess the inappropriateness of the use of antimicrobials and the associated factors among patients admitted in 3 hospitals in southwest Ethiopia.
Methods: A prospective observational study design was employed at medical wards of 3 hospitals in southwest Ethiopia. Data was analyzed using SPSS, version 16.0 using logistic regression model. Statistical significance was considered at p-value <0.05.
Results: A total of 348 antimicrobial containing orders were prescribed for the 291 patients during the 2525 person-days of follow up. At least one antimicrobial use problem was identified among most (80.1%) of the patients. The multivariate logistic regression showed that the use of social drug [AOR=2.549(1.279-5.080) at 95% C.I.; p value=0.008)], the use of antimicrobial in the previous 3 months [AOR=4.095(1.855-9.040) at 95% C.I.; p value=0.000] and the total number of drugs used [AOR=2.997(1.413-6.356); p value=0.004 for 3-4 drugs and AOR=4.653(1.985- 10.906); p value=0.000 for ≥5 drugs at 95% C.I.] were independently associated with antimicrobial use problems.
Conclusion: At least one antimicrobial use problem was prevalent among most of the patients. The independent determinants of antimicrobial use problems were the total number of drugs used, use of social drugs and the previous use of antimicrobials.